3647-71-0

Basic information

• Product Name: N-BENZYL-2-PHENYLETHYLAMINE
• Synonyms: Benzeneethanamine, N-(phenylmethyl)-;N-Benzyl-2-phenylethanamine;BENETHAMINE;CBI-BB ZERO/001789;N-BENZYL-2-PHENYLETHYLAMINE;N-BENZYL-2-PHENETHYLAMINE;N-BENZYL-2-PHENETYLAMINE;TIMTEC-BB SBB000516
• CAS NO: 3647-71-0
• Molecular Formula: C₁₅H₁₇N
• Molecular Weight: 211.3
• EINECS: 222-882-8
• Mol File: 3647-71-0.mol
• Article Data: 80

Chemical Properties

• Melting Point: 61-64 °C
• Boiling Point: 327-328 °C750 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.007 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000178mmHg at 25°C
• Refractive Index: n20/D 1.566(lit.)
• PKA: 9.36±0.19(Predicted)
• CAS DataBase Reference: N-BENZYL-2-PHENYLETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BENZYL-2-PHENYLETHYLAMINE(3647-71-0)
• EPA Substance Registry System: N-BENZYL-2-PHENYLETHYLAMINE(3647-71-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 3647-71-0(Hazardous Substances Data)

Usage

Description

N-BENZYL-2-PHENYLETHYLAMINE, also known as an aromatic amine, is a chemical compound with the formula C15H17N. It is characterized by the presence of a benzyl group attached to the amino group of 2-phenylethanamine. N-BENZYL-2-PHENYLETHYLAMINE exhibits chemical properties of a clear light yellow liquid.

Uses

Used in Pharmaceutical Industry:
N-BENZYL-2-PHENYLETHYLAMINE is used as a synthetic intermediate for the production of various pharmaceutical compounds, particularly dithiocarbamates. Its unique structure allows for the creation of a wide range of therapeutic agents, making it a valuable component in the development of new drugs.
Used in Chemical Synthesis:
N-BENZYL-2-PHENYLETHYLAMINE is used as a key building block in the synthesis of various organic compounds. Its aromatic amine structure provides a versatile platform for further chemical reactions, enabling the production of a diverse array of molecules with potential applications in various industries, such as materials science, agrochemicals, and specialty chemicals.

Synthesis Reference(s)

Tetrahedron Letters, 24, p. 4711, 1983 DOI: 10.1016/S0040-4039(00)86234-6

InChI:InChI=1/C15H17N/c1-3-7-14(8-4-1)11-12-16-13-15-9-5-2-6-10-15/h1-10,16H,11-13H2/p+1

Upstream product

• 854637-14-2 N-benzyl-4-methyl-N-phenethylbenzenesulfonamide 
• 122-78-1 phenylacetaldehyde 
• 100-46-9 benzylamine 
• 140-29-4 phenylacetonitrile 
• 100-51-6 benzyl alcohol 
• 3240-95-7 N-benzylidene-2-phenylethanamine 
• 100-52-7 benzaldehyde 
• 64-04-0 phenethylamine 
• 1788-31-4 1,3-diphenylpropan-2-one oxime 
• 622-24-2 2-phenylethyl chloride 
• 2534-77-2 2-bromobicyclo[2.2.1]heptane 
• 100-42-5 styrene 
• 182121-96-6 2-benzylamino-3-phenylpropanenitrile 
• 64-17-5 ethanol 

Downstream Products

• 102812-44-2 N-benzyl-N-phenethyl-β-alanine-(2-diethylamino-ethyl ester) 
• 55246-62-3 C₁₆H₁₆ClNO 
• 94910-12-0 N-Benzyl-N-phenaethyl-bernsteinsaeure-aethylester-amid 
• 76842-47-2 N-benzyl-N-phenylethyl-2-phenylethanamine 
• 103-65-1 phenylpropane 
• 64-04-0 phenethylamine 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 108-88-3 toluene 
• 141334-84-1 1-Phenethyl-2,3,5-triphenyl-1H-pyrrole 
• 106889-81-0 N-benzyl-N-(phenylethyl)phenacylamine 
• 3240-95-7 (E)-N-(phenylethyl)-1-phenylmethanimine 
• 100-41-4 ethylbenzene 

Relevant articles and documents

Structural Revision of the Ring-Opened Product in the ZnCl 2-Catalyzed Reactions of 1-Benzyl-2-phenylaziridine with Thiols

The reported β-amino sulfide structures for the products in the ZnCl2-catalyzed ring-opening reactions of 1-benzyl-2-phenylaziridine with thiols should be revised to 2-amino-1-phenyl-ethyl sulfides from 2-amino-2-phenylethyl sulfides.

Continuous flow heterogeneous catalytic reductive aminations under aqueous micellar conditions enabled by an oscillatory plug flow reactor

Despite the fact that continuous flow processing exhibits well-established technical advances, aqueous micellar chemistry, a field that has proven extremely useful in shifting organic synthesis to sustainable water-based media, has mostly been explored under conventional batch-based conditions. This is particularly because of the fact that the reliable handling of slurries and suspensions in flow has been considered as a significant technical challenge. Herein, we demonstrate that the strategic application of an oscillatory plug flow reactor enables heterogeneous catalytic reductive aminations in aqueous micellar media enhancing mass transport and facilitating process simplicity, stability and scalability. The micellar flow process enabled a broad range of substrates, including amino acid derivatives, to be successfully transformed under reasonably mild conditions utilizing only very low amounts of Pd/C as a readily available heterogeneous catalyst. The preparative capabilities of the process along with the recyclability of the heterogenous catalyst and the aqueous reaction media were also demonstrated. This journal is

Hydroalkylation of Styrenes with Benzylamines by Potassium Hydride

A method for the synthesis of 1,3-diarylpropylamines through hydroalkylation of styrenes with benzylamines by potassium hydride has been developed. The protocol is initiated by solvothermal treatment of benzylamines with KH at 100 °C to generate deprotonated anionic species, which undergo selective C-alkylation with arylalkenes at 0 °C to ambient temperature to afford 1,3-diarylpropylamines as the major product.