36476-84-3

Basic information

• Product Name: 1-Benzhydryl-3-bromoazetidine
• Synonyms: 1-Benzhydryl-3-bromoazetidine;3-bromo-1-(diphenylmethyl)Azetidine
• CAS NO: 36476-84-3
• Molecular Formula: C₁₆H₁₆BrN
• Molecular Weight: 302.22
• Mol File: 36476-84-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 356.897 °C at 760 mmHg
• Flash Point: 169.646 °C
• Appearance: /
• Density: 1.383 g/cm³
• CAS DataBase Reference: 1-Benzhydryl-3-bromoazetidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzhydryl-3-bromoazetidine(36476-84-3)
• EPA Substance Registry System: 1-Benzhydryl-3-bromoazetidine(36476-84-3)

Safety Data

• Hazardous Substances Data: 36476-84-3(Hazardous Substances Data)

Usage

General Description

1-Benzhydryl-3-bromoazetidine is a chemical compound that belongs to the class of azetidines, which are cyclic organic compounds containing a four-membered ring with three carbon atoms and one nitrogen atom. This particular compound contains a benzhydryl group and a bromine atom attached to the azetidine ring. It is used in organic synthesis and medicinal chemistry as a building block for the preparation of various compounds, and its structure and properties make it useful for the development of potential pharmaceuticals and agrochemicals. Its unique structure and reactivity have also made it a subject of research in the field of chemical and pharmaceutical sciences.

Upstream product

• 33301-41-6 1-benzhydryl-3-azetidinyl methanesulfonate 
• 18621-17-5 1-(diphenylmethyl)-3-hydroxyazetidine 

Downstream Products

• 181941-94-6 diethyl 2-[1-(diphenylmethyl)azetidin-3-yl]propane-1,3-dioate 
• 183062-94-4 1-Benzhydryl-4-hydroxymethyl-pyrrolidin-2-one 
• 183062-93-3 1-Benzhydryl-4-hydroxymethyl-2-oxo-pyrrolidine-3-carboxylic acid 

Relevant articles and documents

Process for synthesizing 1-benzhydrylazetidin-3-formaldehyde

The invention discloses a process for synthesizing 1-benzhydrylazetidin-3-formaldehyde. The process includes the following specific steps: (1) under the action of an alkali, subjecting 1-benzhydrylazetidin-3-ol and phosphorous tribromide to reaction in a dried aprotic solvent to obtain 1-benzhydrylazetidin-3-bromo; (2) in a dried solvent, subjecting the 1-benzhydrylazetidin-3-bromine to reaction with magnesium chips to generate form Grignard reagent; subjecting the Grignard reagent to reaction with dried DMF (dimethyl formamide), carrying quenching reaction with ammonium chloride after reaction, and post-treating to obtain the target product 1-benzhydrylazetidin-3-formaldehyde. The process of the invention is stable to perform, high in yield, low in output of three wastes and low in production cost. The produced product has good quality.

Quantitative structure-activity relationships of antibacterial agents, 7-heterocyclic amine substituted 1-cyclopropyl-6,8-difluoro-4-oxoquinoline-3-carboxylic acids

Quantitative structure-activity relationships (QSAR) of various 7-(3-substituted-azetidin-1-yl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro -4-oxoquinoline-3-carboxylic acids, 14-25, were studied to clarify the structural requirements for 3-substituted azetidi