36476-86-5

Basic information

• Product Name: 1-Benzhydrylazetane-3-carbonitrile
• Synonyms: 3-CYANO-1-(DIPHENYLMETHYL)AZETIDINE;1-BENZHYDRYLAZETANE-3-CARBONITRILE;1-BENZHYDRYL-AZETIDINE-3-CARBONITRILE;1-BENZHYDRYL-3-CYANOAZETIDINE;BUTTPARK 37\04-15;1-BENZHYDRYL-3-CYANOAZETIDINE 98%;1-(Diphenylmethyl)-3-azetidinecarbonitrile;1-(diphenylmethyl)azetidine-3-carbonitrile
• CAS NO: 36476-86-5
• Molecular Formula: C₁₇H₁₆N₂
• Molecular Weight: 248.32
• Product Categories: Azetidine;Aromatics;Heterocycles
• Mol File: 36476-86-5.mol
• Article Data: 12

Chemical Properties

• Melting Point: 150-153°C
• Boiling Point: 384.3 °C at 760 mmHg
• Flash Point: 164 °C
• Appearance: /Solid
• Density: 1.15 g/cm³
• Vapor Pressure: 4.14E-06mmHg at 25°C
• Refractive Index: 1.628
• Storage Temp.: Room temperature.
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 5.61±0.10(Predicted)
• Stability: Good
• CAS DataBase Reference: 1-Benzhydrylazetane-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzhydrylazetane-3-carbonitrile(36476-86-5)
• EPA Substance Registry System: 1-Benzhydrylazetane-3-carbonitrile(36476-86-5)

Safety Data

• Hazard Codes: C
• Statements: 20/21/22-36/37/38-34
• Safety Statements: 26-36/37/39-45
• RIDADR: 3276
• HazardClass: IRRITANT
• Hazardous Substances Data: 36476-86-5(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

InChI:InChI=1/C17H16N2/c18-11-14-12-19(13-14)17(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-10,14,17H,12-13H2

Upstream product

• 33301-41-6 1-benzhydryl-3-azetidinyl methanesulfonate 
• 143-33-9 sodium cyanide 
• 18621-17-5 1-(diphenylmethyl)-3-hydroxyazetidine 
• 773837-37-9 sodium cyanide 
• 91-00-9 Benzhydrylamine 

Downstream Products

• 36476-88-7 3-(aminomethyl)-1-(1,1-diphenylmethyl)azetidine 
• 852655-67-5 1-(1-benzhydryl-azetidin-3-yl)-cyclopropylamine 
• 606129-36-6 (1-benzhydryl-azetidin-3-yl)-(4-chloro-phenyl)-methanone 
• 36476-87-6 1-benzhydrylazetidine-3-carboxylic acid 
• 53871-06-0 1-(diphenylmethyl)-3-methoxycarbonylazetidine 
• 345954-83-8 azetidine-3-carbonitrile hydrochloride 
• 359402-65-6 C₂₃H₂₁NO 
• 1257260-54-0 C₂₃H₂₀FNO 
• 1257260-55-1 C₂₃H₁₉F₂NO 
• 72351-36-1 1-diphenylmethyl-3-hydroxymethylazetidine 
• 1351078-34-6 C₂₅H₃₈N₂O₆P₂ 
• 1391919-91-7 1-benzhydrylazetidin-3-carboxamide 
• 1416149-29-5 1-benzhydryl-3-(3-chloropyridin-4-yl)azetidine-3-carbonitrile 
• 1357614-76-6 1-benzhydryl-3-(2-bromo-4-(diethoxymethyl)phenyl)azetidine-3-carbonitrile 

Relevant articles and documents

NOVEL TRIAZINE COMPOUNDS

The present invention relates to novel triazine compounds of formula (1), methods of their preparation, pharmaceutical compositions containing these compounds and the use of these compounds to treat proliferative disorders such as tumors and cancers and also other conditions and disorders related to or associated with dysregulation of PI3 Kinases, PI3 Kinase pathway, mTOR and/ or the mTOR pathway.

Effect of lipophilicity modulation on inhibition of human rhinovirus capsid binders

To try and generate broad spectrum human rhinovirus VP1 inhibitors with more attractive physicochemical, DMPK and safety profiles, we explored the current SAR of known VP1 compounds. This lead to the identification of specific structural regions where reduction in polarity can be achieved, so guiding chemistry to analogues with significantly superior profiles to previously reported inhibitors.

PYRIDINE OR PYRIMIDINE DERIVATIVE HAVING EXCELLENT CELL GROWTH INHIBITION EFFECT AND EXCELLENT ANTI-TUMOR EFFECT ON CELL STRAIN HAVING AMPLIFICATION OF HGFR GENE

A pyridine or pyrimidine derivative represented by the formula (I) has an excellent HGFR inhibitory activity and exhibits strong cell proliferation inhibitory effect and anti-tumor effect against cancer cell lines with amplified HGFR gene. wherein R1 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; R2 and R3 represent hydrogen; R4, R5, R6, and R7 may be the same or different and each represents hydrogen, halogen, C1-6 alkyl or the like; R8 represents hydrogen or the like; R9 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; n represents an integer of 1 or 2; X represents -CH=, nitrogen.