365-06-0

Basic information

• Product Name: 3'-TRIFLUOROMETHYLBIPHENYL-2-YLAMINE
• Synonyms: AKOS BAR-0102;3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-2-AMINE;3'-TRIFLUOROMETHYLBIPHENYL-2-YLAMINE;3'-TrifluoroMethyl-biphenyl-2-aMine
• CAS NO: 365-06-0
• Molecular Formula: C13H10F3N
• Molecular Weight: 237.22
• Mol File: 365-06-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 314.7 °C at 760 mmHg
• Flash Point: 140.2 °C
• Appearance: /
• Density: 1.245 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 3'-TRIFLUOROMETHYLBIPHENYL-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-TRIFLUOROMETHYLBIPHENYL-2-YLAMINE(365-06-0)
• EPA Substance Registry System: 3'-TRIFLUOROMETHYLBIPHENYL-2-YLAMINE(365-06-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 365-06-0(Hazardous Substances Data)

Usage

General Description

3'-Trifluoromethylbiphenyl-2-ylamine is a chemical compound with the molecular formula C13H10F3N. It is a derivative of biphenyl and is used in the synthesis and production of various pharmaceuticals and agrochemicals. 3'-TRIFLUOROMETHYLBIPHENYL-2-YLAMINE is often used as a building block in organic synthesis due to its unique molecular structure, which can be further modified to create a wide range of functionalized organic compounds. It is a valuable intermediate in the pharmaceutical industry for the development of new drugs and is also used in the production of crop protection chemicals. Additionally, 3'-trifluoromethylbiphenyl-2-ylamine is also used in academic research and in the development of new materials.

Upstream product

• 342-72-3 2'-nitro-3-trifluoromethylbiphenyl 
• 7732-18-5 water 
• 1423-26-3 (meta-(trifluoromethyl)phenyl)boronic acid 
• 615-36-1 2-bromoaniline 
• 401-81-0 m-trifluoromethylphenyl iodide 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 577-19-5 2-nitrophenyl bromide 
• 402-26-6 3-(trifluoromethyl)phenylmagnesium bromide 
• 15111-14-5 2-iodo-N-(phenylmethylene)-benzenamine 
• 615-43-0 2-iodophenylamine 

Downstream Products

• 1448169-49-0 (E)-2'-(1,2-diphenylethenyl)-5'-(trifluoromethyl)[1,1'-biphenyl]-2-amine 
• 1565834-85-6 2-((((3'-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)imino)methylene)amino)benzonitrile 
• 1609211-25-7 N-(5-(trifluoromethyl)-[1,1′-biphenyl]-2-yl)picolinamide 
• 2467-83-6 3-(trifluoromethyl)-9H-carbazole 

Relevant articles and documents

NBE-Controlled Palladium-Catalyzed Interannular Selective C-H Silylation: Access to Divergent Silicon-Containing 1,1′-Biaryl-2-Acetamides

A novel palladium-catalyzed interannular selective C-H silylation of 1,1′-biaryl-2-acetamides is described. The combination of palladium catalyst with copper oxidant enables meta- or ortho-selective C-H silylation by employing hexamethyldisilane as a trimethylsilyl source, which relies on the control of NBE derivatives as a switch, thus providing straightforward access to divergent silicon-containing 1,1′-biaryl-2-acetamides.

Rhodium(I)-Catalyzed Aryl C-H Carboxylation of 2-Arylanilines with CO2

An unprecedented Rh(I)-catalyzed, amino-group-assisted C-H carboxylation of 2-arylanilines with CO2 under redox-neutral conditions has been developed. This reaction was promoted by a phosphine ligand with t-BuOK as the base and did not require the use of additional strong organometallic reagent. It enabled an efficient direct conversion of a broad range of 2-(hetero)arylanilines including electron-deficient heteroarenes to various phenanthridinones. Possible intermediates of the reaction were also evaluated in the preliminary mechanistic studies.

Synthesis of Triphenylenes Starting from 2-Iodobiphenyls and Iodobenzenes via Palladium-Catalyzed Dual C-H Activation and Double C-C Bond Formation

A novel and facile approach for the synthesis of triphenylenes has been developed via palladium-catalyzed coupling of 2-iodobiphenyls and iodobenzenes. The reaction involves dual palladium-catalyzed C-H activations and double palladium-catalyzed C-C bond formations. A range of unsymmetrically functionalized triphenylenes can be synthesized with the reaction. The approach features readily available starting materials, high atom- and step-economy, and access to various unsymmetrically functionalized triphenylenes.