3651-62-5

Basic information

• Product Name: 3-Hydroxy-N-(4-methylphenyl)naphthalene-2-carboxamide
• Synonyms: 3-hydroxy-n-(4-methylphenyl)-2-naphthalenecarboxamid;3-hydroxy-N-(4-methylphenyl)-2-Naphthalenecarboxamide;3-hydroxy-4'-methyl-2-naphthanilide;3-hydroxy-N-p-tolyl-2-naphthamide;3-Hydroxy-4′-methyl-2-naphthanilid;Naphthol AS-RT (C.I. 37521);3-Hydroxy-N-(4-methylphenyl)naphthalene-2-carboxamide;Azoic Coupling Component 31
• CAS NO: 3651-62-5
• Molecular Formula: C₁₈H₁₅NO₂
• Molecular Weight: 277.32
• EINECS: 222-892-2
• Mol File: 3651-62-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 404.9 °C at 760 mmHg
• Flash Point: 198.7 °C
• Appearance: /
• Density: 1.277 g/cm³
• CAS DataBase Reference: 3-Hydroxy-N-(4-methylphenyl)naphthalene-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hydroxy-N-(4-methylphenyl)naphthalene-2-carboxamide(3651-62-5)
• EPA Substance Registry System: 3-Hydroxy-N-(4-methylphenyl)naphthalene-2-carboxamide(3651-62-5)

Safety Data

• Hazardous Substances Data: 3651-62-5(Hazardous Substances Data)

Usage

Preparation

p-Methylaniline and 3-Hydroxy-2-naphthoic acid condensation.

Properties and Applications

red light yellow powder. Insoluble in water, but soluble in pyridine. The strong sulfuric acid and sodium hydroxide solution are yellow liquid, sodium carbonate in solution not dissolve. Melting point for 207 ~ 211 ℃, the air is stable. This product is brown and purplish red render agent, used for cotton, viscose and polyamide fiber dyeing and not used in printing of cotton, cotton to the high affinity.

Upstream product

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• 64-17-5 ethanol 

Downstream Products

• 82813-14-7 p-tolylamide of 1,2-naphthoquinonediazide-⁽¹⁾-3-carboxylic acid 
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• 87950-56-9 2-(p-tolylcarbamoyl)-3-indenecarboxylic acid 
• 87950-58-1 methyl 2-(p-tolylcarbamoyl)-3-indenecarboxylate 

Relevant articles and documents

3-Hydroxynaphthalene-2-carboxanilides and their antitrypanosomal activity

Abstract: Series of ring-substituted 3-hydroxynaphthalene-2-carboxanilides were screened for their in vitro activity against wild-type S427 (bloodstream form) of Trypanosoma brucei brucei. 3-Hydroxy-N-(3-trifluoromethylphenyl)- and 3-hydroxy-N-(4-trifluoromethylphenyl)naphthalene-2-carboxamides showed the highest biological activity (MIC?=?1.56 and 2.08?μmol/dm3, respectively). Antitrypanosomal activity was correlated with the experimentally determined lipophilicity and acid–base dissociation constants of the compounds as well as with the calculated electronic properties of individual anilide substituents expressed as Hammett’s σ parameters. The substitution in the meta- or para-position of anilide of derivatives with higher lipophilicity by an electron-withdrawing moiety is favourable for higher activity. The optimum thermodynamic pKa T value was found to be ca. 7.5. The structure–activity relationships of all compounds are discussed. Graphical abstract: [Figure not available: see fulltext.].

3,3-bis(aryl)-5-((N-(un)substituted)amido)naphthopyrans, their preparation, compositions and (co)polymer matrices containing them

The object of the present invention is novel naphthopyran compounds as well as the compositions and (co)polymer matrices containing them. Said compounds have interesting photochromic properties. Another object of the present invention is a method of preparing said novel compounds.