366-38-1Relevant articles and documents
The observation of a large gauche preference when 2-fluoroethylamine and 2-fluoroethanol become protonated
Briggs, Caroline R.S.,Allen, Mark J.,O'Hagan, David,Tozer, David J.,Slawin, Alexandra M.Z.,Goeta, Andres E.,Howard, Judith A.K.
, p. 732 - 740 (2004)
The energies of the gauche and anti conformers of 2-fluoroethylamine, 2-fluoroethanol and their protonated analogues are calculated using density functional theory. Unlike the non protonated systems, the protonated systems show a strong gauche effect where the C-F and the C-+NH3 or C-F and C-+OH2 bonds are gauche rather than anti to each other. Single crystal X-ray diffraction studies of 2-fluoroethylammonium compounds identify the same conformational preference.
A NOVEL PROCESS FOR PREPARING 3-AMINO-5-FLUORO-4-DIALKOXYPENTANOIC ACID ESTER
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Page/Page column 19, (2008/06/13)
The present invention relates to a novel process for the production of 3-amino-5- fluoro-4-dialkoxypentanoic acid ester used in the precursor of 3-amino-5-fluoro-4- oxopentanoic acid, represented by the following formula (I) : wherein R1 and R2 are as def