366454-36-6

Basic information

• Product Name: EB-47
• Synonyms: EB-47;4-[1-(6-AMino-9H-purin-9-yl)-1-deoxy-β-D- ribofuranuronoyl]-N-(2,3-dihydro-1-oxo-1H-isoindol-4-yl)-1-piperazineacetaMide Dihydrochloride;5'-Deoxy-5'-[4-[2-[(2,3-dihydro-1-oxo-1H-isoindol-4-yl)aMino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine Dihydrochloride;EB 47 DIHYDROCHLORIDE;PARP Inhibitor IX, EB-47
• CAS NO: 366454-36-6
• Molecular Formula: C24H27N9O6
• Molecular Weight: 537.53
• Product Categories: PARP Poly(ADP-ribose) Polymerase;Enzyme Inhibitors by Enzyme;P to
• Mol File: 366454-36-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /solid
• Storage Temp.: −20°C
• Solubility: H2O: 10 mg/mL, soluble
• CAS DataBase Reference: EB-47(CAS DataBase Reference)
• NIST Chemistry Reference: EB-47(366454-36-6)
• EPA Substance Registry System: EB-47(366454-36-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 366454-36-6(Hazardous Substances Data)

Usage

Description

EB-47 is a potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1), a key enzyme involved in cellular survival and the maintenance of energy stores following genotoxic stress. It has been found to have significant applications in various fields due to its ability to target PARP-1.

Uses

Used in Pharmaceutical Industry:
EB-47 is used as a therapeutic agent for targeting PARP-1, which plays a crucial role in cellular survival and energy maintenance after genotoxic insult. Its inhibition can lead to the disruption of these processes, making it a potential candidate for the development of treatments for various diseases and conditions.
Used in Cancer Research:
EB-47 is used as a research tool in cancer biology to study the role of PARP-1 in tumor development and progression. By inhibiting PARP-1, researchers can gain insights into the molecular mechanisms underlying cancer and identify potential therapeutic targets for the development of novel anticancer drugs.
Used in Drug Development:
EB-47 is used as a lead compound in the development of new drugs targeting PARP-1. Its potent inhibitory activity against PARP-1 makes it a valuable starting point for the design and synthesis of more effective and selective PARP inhibitors with improved pharmacological properties.
Used in Cellular Stress Response Studies:
EB-47 is used as a research tool to investigate the role of PARP-1 in cellular stress response. By studying the effects of EB-47 on cellular processes, researchers can better understand the mechanisms by which cells respond to genotoxic stress and develop strategies to modulate these responses for therapeutic benefit.

Upstream product

• 366454-72-0 2-{4-[6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carbonyl]-piperazin-1-yl}-N-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)-acetamide 
• 59382-59-1 2-methyl-3-nitro-benzoic acid methyl ester 
• 98475-07-1 2-bromomethyl-3-nitro-benzoic acid methyl ester 
• 366452-98-4 4-amino-2,3-dihydro-1H-isoindol-1-one 
• 366452-97-3 4-nitroisoindolin-1-one 
• 366452-99-5 2-chloro-N-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)-acetamide 
• 366453-67-0 4-[(1-oxo-2,3-dihydro-1H-isoindol-4-ylcarbamoyl)-methyl]-piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: Potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1)

A series of novel 4-(N-acyl)-2,3-dihydro-1H-isoindol-1-ones have been prepared from methyl-3-nitro-2-methylbenzoate and linked through various spacers to the adenosine derivatives 11 and 12. We found that potent inhibition of poly(ADP-ribose)polymerase-1 (PARP-1) was achieved when isoindolinone was linked to adenosine by a spacer group of a specific length. Introduction of piperazine and succinyl linkers between the isoindolinone and adenosine core structures resulted in highly potent compounds 8a and 10b, which showed IC 50 values of 45 and 100 nM, respectively.