367281-00-3Relevant articles and documents
Asymmetric synthesis of crispine A: Constructing tetrahydroisoquinoline scaffolds using pummerer cyclizations
Rotte, Sateesh Chandra Kumar,Chittiboyina, Amar G.,Khan, Ikhlas A.
, p. 6355 - 6360 (2013/10/21)
For the first time, a concise, linear and stereoselective synthesis of both enantiomers of the natural product crispine A has been achieved in six steps with an overall yield of ≥ 20 %, starting from commercially available veratraldehyde. Asymmetric Keck allylation and trifluoroacetic anhydride-mediated Pummerer cyclization were the key transformations used to construct the tetrahydroisoquinoline core structure. Copyright
beta-Cycloylpropionitriles; reduction to 2-cyclyl-delta2-pyrrolines and
KNOTT
, p. 186 - 188 (2007/10/04)
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