36748-88-6 Usage
Description
3-IODO-BENZO[B]THIOHENE, also known as 3-iodobenzo[b]thiophene, is a heterocyclic aromatic compound with the molecular formula C8H5IS. It features a benzene ring fused to a thiophene ring, with an iodine substituent at the 3-position. This unique structure makes it a versatile building block in various fields.
Uses
Used in Pharmaceutical Industry:
3-IODO-BENZO[B]THIOHENE is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 3-IODO-BENZO[B]THIOHENE is utilized as a building block for the creation of novel agrochemicals, potentially enhancing crop protection and yield.
Used in Materials Science:
3-IODO-BENZO[B]THIOHENE is employed as a component in the development of advanced materials, leveraging its unique chemical structure to improve material properties.
Used in Electronics Industry:
3-IODO-BENZO[B]THIOHENE is used as a precursor in the production of electronic materials, such as organic semiconductors and conducting polymers, due to its electronic properties and potential to enhance device performance.
Used in Chemical Research:
As an important intermediate, 3-IODO-BENZO[B]THIOHENE is utilized in various chemical reactions and transformations, contributing to the advancement of chemical science and the discovery of new compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 36748-88-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,7,4 and 8 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 36748-88:
(7*3)+(6*6)+(5*7)+(4*4)+(3*8)+(2*8)+(1*8)=156
156 % 10 = 6
So 36748-88-6 is a valid CAS Registry Number.
36748-88-6Relevant articles and documents
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Gaertner
, p. 4950 (1952)
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Nucleophilic C-H Etherification of Heteroarenes Enabled by Base-Catalyzed Halogen Transfer
Puleo, Thomas R.,Klaus, Danielle R.,Bandar, Jeffrey S.
, p. 12480 - 12486 (2021/08/24)
We report a general protocol for the direct C-H etherification of N-heteroarenes. Potassium tert-butoxide catalyzes halogen transfer from 2-halothiophenes to N-heteroarenes to form N-heteroaryl halide intermediates that undergo tandem base-promoted alcohol substitution. Thus, the simple inclusion of inexpensive 2-halothiophenes enables regioselective oxidative coupling of alcohols with 1,3-azoles, pyridines, diazines, and polyazines under basic reaction conditions.
Photocatalytic Oxidative Iodination of Electron-Rich Arenes
Narobe, Rok,Düsel, Simon J. S.,Iskra, Jernej,K?nig, Burkhard
supporting information, p. 3998 - 4004 (2019/07/17)
A visible-light-mediated oxidative iodination of electron-rich arenes has been developed. 2.5 mol% of unsubstituted anthraquinone as photocatalyst were used in combination with elementary iodine, trifluoroacetic acid and oxygen as the terminal oxidant. The iodination proceeds upon irradiation in non- or weakly-electron donating solvents (DCM, DCE and benzene) wherein a spectral window in strongly coloured iodine solutions can be observed at around 400 nm. The method provides good to excellent yields (up to 98%) and shows excellent regioselectivity and good functional group tolerance (triple bonds, ketone, ester, amide). Moreover, the photo-iodination was also upscaled to a 5 mmol scale (1.1 g). Mechanistic investigations by intermediate trapping and competition experiments indicate a photocatalytic arene oxidation and the subsequent reaction with iodine as a likely mechanistic pathway. (Figure presented.).
