36778-15-1

Basic information

• Product Name: 3-Isothiazolecarboxylic acid, 5-nitro-
• Synonyms: 3-Isothiazolecarboxylic acid, 5-nitro-;5-nitroisothiazole-3-carboxylic acid;5-nitro-1,2-thiazole-3-carboxylic acid
• CAS NO: 36778-15-1
• Molecular Formula: C₄H₂N₂O₄S
• Molecular Weight: 174.13
• Product Categories: API intermediates
• Mol File: 36778-15-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 253.795°C at 760 mmHg
• Flash Point: 107.292°C
• Appearance: /
• Density: 1.804g/cm³
• Vapor Pressure: 0.009mmHg at 25°C
• Refractive Index: 1.674
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Isothiazolecarboxylic acid, 5-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Isothiazolecarboxylic acid, 5-nitro-(36778-15-1)
• EPA Substance Registry System: 3-Isothiazolecarboxylic acid, 5-nitro-(36778-15-1)

Safety Data

• Hazardous Substances Data: 36778-15-1(Hazardous Substances Data)

Usage

General Description

3-Isothiazolecarboxylic acid, 5-nitro- is a chemical compound with the molecular formula C5H3N3O4S. It is a derivative of isothiazolecarboxylic acid that contains a nitro group at the 5-position. 3-Isothiazolecarboxylic acid, 5-nitro- has potential applications in the pharmaceutical industry, specifically in the development of new drugs. It may also have use in research and development, as well as in the production of certain types of chemical compounds. However, as with any chemical, proper handling and precautions should be taken when working with 3-Isothiazolecarboxylic acid, 5-nitro- to ensure safety and proper use.

InChI:InChI=1/C4H2N2O4S/c7-4(8)2-1-3(6(9)10)11-5-2/h1H,(H,7,8)

Upstream product

• 36778-16-2 3-methyl-5-nitroisothiazole 

Downstream Products

• 1094070-50-4 C₅H₄N₂O₄S 
• 481687-38-1 5-nitro-N-para-[4-(trifluoromethyl)phenoxy] phenyl-isothiazole-3-carboxamide 
• 36778-14-0 5-nitro-isothiazole-3-carbonyl chloride 
• 59038-02-7 (5-nitroisothiazol-3-yl)(4-methylpiperazin-1-yl)methanone 

Relevant articles and documents

CYCLIC COMPOUNDS AND METHODS OF USING SAME

The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof which are MALT1 inhibitors. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for treating diseases, such as cancer, autoimmune disorders, and inflammatory disorders.

New geldanamycin derivatives with anti Hsp properties by mutasynthesis

Mutasynthetic supplementation of the AHBA blocked mutant strain of S. hygroscopicus, the geldanamycin producer, with 21 aromatic and heteroaromatic amino acids provided new nonquinoid geldanamycin derivatives. Large scale (5 L) fermentation provided four new derivatives in sufficient quantity for full structural characterisation. Among these, the first thiophene derivative of reblastatin showed strong antiproliferative activity towards several human cancer cell lines. Additionally, inhibitory effects on human heat shock protein Hsp90α and bacterial heat shock protein from H. pylori HpHtpG were observed, revealing strong displacement properties for labelled ATP and demonstrating that the ATP-binding site of Hsps is the target site for the new geldanamycin derivatives.