3679-65-0Relevant articles and documents
Multifunctional bio-based phenol-amine antioxidant, as well as preparation method and application thereof
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Paragraph 0132, (2019/02/19)
The invention discloses a multifunctional bio-based phenol-amine antioxidant. The multifunctional bio-based phenol-amine antioxidant includes a compound with a structure shown as a formula in the description, wherein the structural formula of any one of R
Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1- phosphate uridyltransferase (GlmU)
Tran, Anh Thu,Wen, Daying,West, Nicholas P.,Baker, Edward N.,Britton, Warwick J.,Payne, Richard J.
supporting information, p. 8113 - 8126 (2013/12/04)
Peptidoglycan is an essential component of the cell wall of bacteria, including Mycobacterium tuberculosis, that provides structural strength and rigidity to enable internal osmotic pressure to be withstood. The first committed step in the biosynthesis of peptidoglycan involves the formation of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) from uridine triphosphate (UTP) and GlcNAc-1-phosphate. This reaction is catalysed by N-acetylglucosamine- 1-phosphate uridyltransferase (GlmU), a bifunctional enzyme with two independent active sites that possess acetyltransferase and uridyltransferase activities. Herein, we report the first inhibition study targeted against the uridyltransferase activity of M. tuberculosis GlmU. A number of potential inhibitors were initially prepared leading to the discovery of active aminoquinazoline-based compounds. The most potent inhibitor in this series exhibited an IC50 of 74 μM against GlmU uridyltransferase activity and serves as a promising starting point for the discovery of more potent inhibitors.