36798-79-5

Basic information

• Product Name: Budralazine
• Synonyms: PTLZ;1-(2-(1,3-DIMETHYL-2-BUTENYLIDENE)HYDRAZINO)PHTHALAZINE;1,2-DIHYDROPHTHALAZIN-1-ONE;1,2H-PHTHALAZONE;1,3-DIHYDRO-4-KETO-2 3-BENZODIAZINE;DIHYDROOXOPHTHALAZINE;BUDRALAZINE;1-[2-(1,3-Dimethyl-2-buten-1-ylidene)hydrazino]phthalazine
• CAS NO: 36798-79-5
• Molecular Formula: C14H16N4
• Molecular Weight: 240.31
• EINECS: 204-319-8
• Mol File: 36798-79-5.mol
• Article Data: 0

Chemical Properties

• Melting Point: 183-185 °C(lit.)
• Boiling Point: 373.02°C (rough estimate)
• Flash Point: 222°C
• Appearance: /
• Density: 1.1506 (rough estimate)
• Vapor Pressure: 4.6E-08mmHg at 25°C
• Refractive Index: 1.6000 (estimate)
• Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
• Stability: Light Sensitive
• CAS DataBase Reference: Budralazine(CAS DataBase Reference)
• NIST Chemistry Reference: Budralazine(36798-79-5)
• EPA Substance Registry System: Budralazine(36798-79-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: TH9185000
• Hazardous Substances Data: 36798-79-5(Hazardous Substances Data)

Usage

Description

Budralazine, also known by its brand name BUTERAZINE, is an antihypertensive agent that belongs to the class of direct-acting vasodilators. It is structurally related to hydralazine but is somewhat less potent and is known to produce less tachycardia, making it a preferred choice for certain patients.

Uses

Used in Pharmaceutical Industry:
Budralazine is used as an antihypertensive agent for the treatment of hypertension. It functions as a direct-acting vasodilator, which means it helps to widen the blood vessels, allowing for better blood flow and reduced pressure on the heart and arterial walls.
Used in Cardiovascular Applications:
In the field of cardiology, Budralazine is utilized to manage high blood pressure and related cardiovascular conditions. Its vasodilating properties contribute to the regulation of blood pressure and the prevention of potential complications associated with hypertension, such as heart attacks, strokes, and kidney damage.
Used in Combination Therapy:
Budralazine is also used in combination with other antihypertensive medications to enhance the overall effectiveness of treatment. This combination approach can help achieve better control of blood pressure and reduce the risk of side effects associated with higher doses of individual medications.

Manufacturing Process

A mixture of 2.0 g of 1-hydrazinophthalazine hydrochloride, 1.1 g of mesityl oxide (isoproplyideneacetone) and 100 ml of ethanol, was refluxed for 3 hours. The reaction mixture was concentrated in vacuo and the residue was dissolved in water. The water solution was neutralized with sodium bicarbonate, salted out and the product was extracted with benzene. The benzene layer was passed through a comparatively short column of alumina and the solvent was removed. The residue was crystallized from ether to give 0.7 g of 1-(1,3-dimethyl-2-butenylidene) hydrazinophthalazine, melting point 131°-132°C.

Therapeutic Function

Antihypertensive

InChI:InChI=1/C14H16N4/c1-10(2)8-11(3)16-18-14-13-7-5-4-6-12(13)9-15-17-14/h4-9H,1-3H3,(H,17,18)/b16-11+