368424-95-7

Basic information

• Product Name: 4-Oxazolidinecarboxylicacid,5-methyl-,methylester,(4S,5R)-(9CI)
• Synonyms: 4-Oxazolidinecarboxylicacid,5-methyl-,methylester,(4S,5R)-(9CI)
• CAS NO: 368424-95-7
• Molecular Formula: C₆H₁₁NO₃
• Molecular Weight: 145.16
• Product Categories: CARBOXYLICESTER
• Mol File: 368424-95-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 190.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.088±0.06 g/cm3(Predicted)
• PKA: 6.25±0.60(Predicted)
• CAS DataBase Reference: 4-Oxazolidinecarboxylicacid,5-methyl-,methylester,(4S,5R)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Oxazolidinecarboxylicacid,5-methyl-,methylester,(4S,5R)-(9CI)(368424-95-7)
• EPA Substance Registry System: 4-Oxazolidinecarboxylicacid,5-methyl-,methylester,(4S,5R)-(9CI)(368424-95-7)

Safety Data

• Hazardous Substances Data: 368424-95-7(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 39994-75-7 L-threonine methyl ester hydrochloride 
• 3373-59-9 L-threonine methyl ester 
• 110-88-3 1,3,5-Trioxan 

Downstream Products

• 95599-23-8 N-methyl-L-threonine methyl ester 

Relevant articles and documents

THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF

The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Papuamides A-D, HIV-inhibitory and cytotoxic depsipeptides from the sponges Theonella mirabilis and Theonella swinhoei collected in Papua New Guinea

The novel cyclic depsipeptides papuamides A (1), B (2), C (3), and D (4) have been isolated from Papua New Guinea collections of the sponges Theonella mirabilis and Theonella swinhoei. Their structures were determined by a combination of spectroscopic analysis and chemical degradation and derivatization studies. In addition to glycine, alanine, and threonine, these peptides contain a number of unusual amino acids including 3,4- dimethylglutamine, β-methoxytyrosine, 3-methoxyalanine, and 2,3- diaminobutanoic acid or 2-amino-2-butenoic acid residues. Papuamides A-D (1- 4) are also the first marine-derived peptides reported to contain 3- hydroxyleucine and homoproline residues. These peptides also contain a previously undescribed 2,3-dihydroxy-2,6,8-trimethyldeca-(4Z,6E)-dienoic acid moiety N-linked to a terminal glycine residue. Papuamides A (1) and B (2) inhibited the infection of human T-lymphoblastoid cells by HIV-1(RF) in vitro with an EC50 of approximately 4 ng/mL. Compound 1 was also cytotoxic against a panel of human cancer cell lines with a mean IC50 of 75 ng/mL.