36880-33-8

Basic information

• Product Name: 5-Ethyl-2-thiophenecarboxaldehyde
• Synonyms: 5-ethyl-2-thiophenecarboxaldehyd;ART-CHEM-BB B003568;5-ETHYL-2-THIOPHENECARBALDEHYDE;5-ETHYL-2-THIOPHENECARBOXALDEHYDE;5-ETHYL-THIOPHENE-2-CARBALDEHYDE;5-ETHYLTHIOPHENE-2-CARBOXALDEHYDE;AKOS B003568;2-ETHYL-5-FORMYLTHIOPHENE
• CAS NO: 36880-33-8
• Molecular Formula: C₇H₈OS
• Molecular Weight: 140.2
• EINECS: 253-252-0
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Thiophenes
• Mol File: 36880-33-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 65°C
• Boiling Point: 65 °C2 mm Hg(lit.)
• Flash Point: 229 °F
• Appearance: clear red-brown to brown liquid
• Density: 1.12 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0766mmHg at 25°C
• Refractive Index: n20/D 1.57(lit.)
• Storage Temp.: Refrigerator
• Sensitive: Air Sensitive
• BRN: 108539
• CAS DataBase Reference: 5-Ethyl-2-thiophenecarboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Ethyl-2-thiophenecarboxaldehyde(36880-33-8)
• EPA Substance Registry System: 5-Ethyl-2-thiophenecarboxaldehyde(36880-33-8)

Safety Data

• Statements: 20/21/22
• Safety Statements: 24/25
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 36880-33-8(Hazardous Substances Data)

Usage

Description

5-Ethyl-2-thiophenecarboxaldehyde is an alkyl derivative of thiophenecarboxaldehyde, a heterocyclic compound with a sulfur atom in the ring structure. It has been studied for its standard molar enthalpies of combustion and vaporization, indicating its potential for various applications in chemical synthesis and material science.

Uses

Used in Pharmaceutical Industry:
5-Ethyl-2-thiophenecarboxaldehyde is used as a key intermediate in the synthesis of various pharmaceutical compounds. For instance, it plays a crucial role in the preparation of 6-(butylamino)-2-(5-ethylthiophen-2-yl)-3-(4-fluorobenzyl)-2,3-dihydroquinazolin-4(1H)-one, a compound with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, 5-Ethyl-2-thiophenecarboxaldehyde serves as a valuable building block for creating a wide range of organic compounds, particularly those with heterocyclic structures. Its unique properties make it suitable for use in the development of new materials and chemicals with specific functionalities.
Used in Material Science:
The material properties of 5-Ethyl-2-thiophenecarboxaldehyde, including its standard molar enthalpies of combustion and vaporization, suggest that it could be utilized in the development of novel materials with tailored characteristics. These materials could find applications in various industries, such as electronics, aerospace, and automotive, where high-performance materials are in demand.

InChI:InChI=1/C7H8OS/c1-2-6-3-4-7(5-8)9-6/h3-5H,2H2,1H3

Upstream product

• 872-55-9 2-ethylthiophene 
• 93-61-8 N-methyl-N-phenylformamide 
• 859488-51-0 2-ethyl-5-chloromethyl-thiophene 
• 100-97-0 hexamethylenetetramine 
• 68-12-2 N,N-dimethyl-formamide 
• 122-51-0 orthoformic acid triethyl ester 
• 15022-15-8 2-thienylacetaldehyde 
• 542-88-1 bis(2-chloromethyl)ether 
• 40323-88-4 2-methyl-5-ethyli-thiophene 

Downstream Products

• 92855-85-1 4-(5-ethyl-thiophen-2-ylmethylene)-2-phenyl-4H-oxazol-5-one 
• 581-58-8 3c-(5-ethyl-[2]thienyl)-2-(4-fluoro-phenyl)-acrylonitrile 
• 113795-92-9 (5-ethyl-[2]thienyl)-bis-(4-dimethylamino-phenyl)-methane 
• 36634-74-9 (E)-2-ethyl-5-styrylthiophene 
• 23229-72-3 5-ethyl-2-thiophenecarboxylic acid 
• 159058-69-2 (5-Ethyl-thiophen-2-yl)-methanol 
• 36880-34-9 3-bromo-2-ethyl-5-formylthiophene 
• 359877-57-9 N-(1-((5-ethylthien-2-yl)methyl)piperidin-4-yl)-N-((4-methylphenyl)methyl)-N'-phenylmethylcarbamide 
• 192810-13-2 (5-ethyl-2-thiophene-yl)methyl benzoate 
• 761425-02-9 (3-bromophenyl)-(5-ethyl-thien-2-yl)-methanol 

Relevant articles and documents

KINETICS OF THE FORMYLATION OF THIOPHENE DERIVATIVES WITH N,N-DIMETHYLFORMAMIDE

The kinetics of the formylation of five thiophene derivatives in the presence of phosphorus oxychloride and the formylation of thiophene in the presence of thionyl chloride were investigated.The effect of the condensing agent on the reaction rate is shown, and rate constants and the activation parameters are calculated.The isokinetic dependence and the Hammett dependence of the reactivities on the structure were established for this reaction series.The effect of the solvent on the formylation was studied.

Aryl [a] indole [2,3 - the g] and quinolizine compound, preparation method thereof, pharmaceutical compositions and uses thereof

The invention relates to an aryl [a] indole [2,3-g] quinolizine compound as well as a preparation method, a pharmaceutical composition and application thereof, and particularly relates to a aryl [a] indole [2,3-g] quinolizine compound with a novel structure as shown in a general formula (I) and a derivative, a preparation method and a pharmaceutical composition thereof and application of the aryl [a] indole [2,3-g] quinolizine compound in preparation of a drug for treating diseases related to alpha 1-adrenoreceptor and urinary system diseases, such as benign prostatic hyperplasia, uroschesis and bladder outlet obstruction, especially.

Synthesis of novel thiophene-based chiral ligands and their application in asymmetric Henry reaction

Novel chiral thiolated amino alcohols were synthesized from norephedrine and thiophene carbaldehydes (methyl- or ethyl-substituted) and applied to the catalytic asymmetric Henry reaction of various aldehydes with nitromethane to provide β-hydroxy nitroalkanols in high conversion (92%). The reaction was optimized in terms of the metal, solvent, temperature and amount of chiral ligand. The corresponding catalyst with Cu(OTf)2 and 2-propanol as the solvent provided the best enantioselectivities (up to 96% ee) of the corresponding nitroalcohols for aliphatic aldehydes. Copyright 2013 John Wiley & Sons, Ltd. Chiral thiophene contanining amino alcohol ligands were synthesized from norephedrine and substituted 5-thiophene-2-carbaldehyde. This novel chiral ligands were used to catalyze enantioselective Henry reaction of various aldehydes and nitroalkanes in high yields with good to high enantio- and diastereoselectivities. Copyright