36889-13-1

Basic information

• Product Name: L-NIO DIHYDROCHLORIDE
• Synonyms: n(g)-iminoethylornithine;L-NIO;L-NIO, 2HCL;L-NIO DIHYDROCHLORIDE;L-N5-(1-IMINOETHYL)-ORNITHINE 2HCL;L-N5-(1-IMINOETHYL)ORNITHINE, DIHYDROCHLORIDE;L-N5-(1-IMINOETHYL) ORNITHINE, HYDROCHLORIDE;L-N5-(I-IMINOETHYL)ORNITHINE HYDROCHLORIDE
• CAS NO: 36889-13-1
• Molecular Formula: C7H15N3O2.2ClH
• Molecular Weight: 246.14
• Product Categories: Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Nitric Oxide Reagents;Nitric Oxide
• Mol File: 36889-13-1.mol
• Article Data: 0

Chemical Properties

• Melting Point: 225-226°C
• Boiling Point: 358.9 °C at 760 mmHg
• Flash Point: 170.9 °C
• Appearance: /
• Density: 1.26 g/cm³
• Vapor Pressure: 4E-06mmHg at 25°C
• Storage Temp.: -20°C
• Solubility: Methanol (Slightly), Water (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: L-NIO DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: L-NIO DIHYDROCHLORIDE(36889-13-1)
• EPA Substance Registry System: L-NIO DIHYDROCHLORIDE(36889-13-1)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 36889-13-1(Hazardous Substances Data)

Usage

Description

L-NIO DIHYDROCHLORIDE, also known as L-Nitroarginine Dihydrochloride, is a non-selective inhibitor of all Nitric Oxide Synthase (NOS) isoforms. It is a white crystalline solid that plays a crucial role in various physiological processes by inhibiting the production of nitric oxide. L-NIO has been found to be effective against nNOS (rat), eNOS (bovine), and iNOS (mouse) with Ki values of 1.7, 3.9, and 3.9 μM, respectively. It also inhibits endothelial-dependent relaxation induced by acetylcholine in rat aortic rings and hypotensive responses to acetylcholine and bradykinin.

Uses

Used in Pharmaceutical Industry:
L-NIO DIHYDROCHLORIDE is used as a research chemical for studying the role of nitric oxide in various physiological processes. Its ability to inhibit NOS isoforms makes it a valuable tool in understanding the underlying mechanisms of diseases and conditions related to nitric oxide production.
Used in Cardiovascular Research:
L-NIO DIHYDROCHLORIDE is used as a research compound to investigate the role of nitric oxide in the cardiovascular system. It helps researchers understand the endothelium-dependent relaxation and hypotensive responses to acetylcholine and bradykinin, which are essential for maintaining vascular health and blood pressure regulation.
Used in Neurological Research:
L-NIO DIHYDROCHLORIDE is used as a research tool in the field of neuroscience to study the role of nitric oxide in the brain. By inhibiting the NOS isoforms, it aids in understanding the neurochemical processes and signaling pathways that involve nitric oxide, which can be crucial for developing treatments for neurological disorders.
Used in Adrenal Gland Research:
L-NIO DIHYDROCHLORIDE is used as an inhibitor of NO synthase in adrenal glands, providing insights into the role of nitric oxide in the adrenal gland function and its potential implications in various endocrine and metabolic processes.

Biological Activity

Potent inhibitor of endothelial NO synthase (IC 50 = 500 nM). Also inhibits iNOS and nNOS. Active in vivo .

InChI:InChI=1/C7H15N3O2/c1-5(8)10-4-2-3-6(9)7(11)12/h6H,2-4,9H2,1H3,(H2,8,10)(H,11,12)/p+1/t6-/m0/s1