36947-70-3

Basic information

• Product Name: 1H-Benzimidazole,2-cyclohexyl-(9CI)
• Synonyms: 1H-Benzimidazole,2-cyclohexyl-(9CI);2-Cyclohexylbenzimidazole;BENZIMIDAZOLE, 2-CYCLOHEXYL-;2-cyclohexyl-1H-benzo[d]imidazole
• CAS NO: 36947-70-3
• Molecular Formula: C₁₃H₁₆N₂
• Molecular Weight: 200.283
• Product Categories: BENZIMIDAZOLE
• Mol File: 36947-70-3.mol
• Article Data: 48

Chemical Properties

• Boiling Point: 414.9°Cat760mmHg
• Flash Point: 220.9°C
• Appearance: /
• Density: 1.136g/cm³
• Vapor Pressure: 1.03E-06mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: 1H-Benzimidazole,2-cyclohexyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole,2-cyclohexyl-(9CI)(36947-70-3)
• EPA Substance Registry System: 1H-Benzimidazole,2-cyclohexyl-(9CI)(36947-70-3)

Safety Data

• Hazardous Substances Data: 36947-70-3(Hazardous Substances Data)

Usage

Heterocyclic organic compound

It contains a benzene ring fused to an imidazole ring, which gives the compound its unique properties and reactivity.

Benzimidazole derivative

The presence of the benzene ring and imidazole ring together classifies this compound as a benzimidazole derivative.

Cyclohexyl-substituted

The imidazole ring has a cyclohexyl group attached to it, making it a cyclohexyl-substituted benzimidazole derivative.

Potential pharmaceutical applications

1H-Benzimidazole,2-cyclohexyl-(9CI) may be used as a building block in the synthesis of pharmaceutical drugs or drug intermediates due to its unique structure and reactivity.

Chemical reactivity and functional groups

The specific properties and potential uses of this compound depend on its chemical reactivity and the presence of functional groups, which would require further research and testing to fully understand.

Need for further research and testing

To fully understand the potential uses and applications of 1H-Benzimidazole,2-cyclohexyl-(9CI), additional research and testing are necessary.

InChI:InChI=1/C13H16N2/c1-2-6-10(7-3-1)13-14-11-8-4-5-9-12(11)15-13/h4-5,8-10H,1-3,6-7H2,(H,14,15)

Upstream product

• 98-95-3 nitrobenzene 
• 95-54-5 1,2-diamino-benzene 
• 2043-61-0 cyclohexanecarbaldehyde 
• 716-79-0 2-phenyl-1H-benzoimidazole 
• 51-17-2 benzoimidazole 
• 98-89-5 Cyclohexanecarboxylic acid 
• 88-74-4 2-nitro-aniline 
• 766-05-2 cyclohexane carbonitrile 
• 62-53-3 aniline 
• 100-49-2 cyclohexylmethyl alcohol 
• 166985-85-9 N-phenylcyclohexanecarboximidamide 
• 22651-87-2 cyclohexanecarboxylic acid anhydride 
• 400-98-6 4-trifluoromethyl-2-nitroaniline 
• 110-82-7 cyclohexane 

Downstream Products

• 97968-84-8 Ethyl (2-cyclohexyl-1-benzimidazolyl)acetate 
• 97968-88-2 (2-Cyclohexyl-1-benzimidazolyl)acetic acid 
• 838867-22-4 2-cyclohexyl-1-(prop-2-yn-1-yl)-1H-benzimidazole 
• 1452819-96-3 5-[3-(2-cyclohexyl-1H-benzimidazol-1-yl)prop-1-yn-1-yl]-1-(tetrahydrothien-2-yl)cytosine 

Relevant articles and documents

Heterogenizing a Homogeneous Nickel Catalyst Using Nanoconfined Strategy for Selective Synthesis of Mono- And 1,2-Disubstituted Benzimidazoles

A homogeneous Ni-phenanthroline catalyst was successfully immobilized into the cavities of a metal-organic framework, ZIF-8. The as-synthesized heterogeneous catalyst, Ni-Phen@ZIF, represents the first MOF based catalyst that enables dehydrogenative coupling of alcohols with aromatic diamines for selective synthesis of both mono- and 1,2-disubstituted benzimidazoles. The catalyst survived under harsh basic conditions, characterized by SEM, TEM, BET, PXRD, and EDX elemental mappings. The presence of the nanoconfined Ni-phenanthroline complex and the formation of extra Lewis acid sites during catalysis in the Ni-Phen@ZIF structure, confirmed by TPD analysis and kinetic experiments, might be responsible for higher activity and selectivity.

Visible-light-mediated organoboron-catalysed metal-free dehydrogenation of N-heterocycles using molecular oxygen

The surge of photocatalytic transformation not only provides unprecedented synthetic methods, but also triggers the enthusiasm for more sustainable photocatalysts. On the other hand, oxygen is an ideal oxidant in terms of atom economy and environmental friendliness. However, the poor reactivity of oxygen at the ground state makes its utilization challenging. Herein, a visible-light-induced oxidative dehydrogenative process is disclosed, which uses an organoboron compound as the photocatalyst and molecular oxygen as the sole oxidant.Viathis approach, an array of N-heterocycles have been accessed under metal-free mild conditions, in good to excellent yields.

Preparation method 2 -substituted benzimidazole derivative

The invention belongs to the field of fine chemical product production, and particularly relates to 2 -substituted benzimidazole derivative preparation method which comprises the following steps: (1) taking O-phenylenediamine and aldehyde as raw materials, carrying out catalytic condensation, cyclization and oxidation reaction in a eutectic solvent. (2) Water is added to the reaction system, the separated product is filtered, and the eutectic solvent is recycled. (3) After recrystallization, a target product is obtained. The method has the advantages of simple operation process, easily available raw materials, low cost, high purity of the target product and no catalyst participation, can effectively prevent isomer formation, and is beneficial to large-scale production.