36953-40-9

Basic information

• Product Name: 2-BROMO-4-HYDROXYPYRIDINE
• Synonyms: (S)-1-[2-(Diphenylphosphino)phenyl]ethanaMiniuM tetrafluoroborate;(S)-1-AMino-8-(diphenylphosphino)-1,2,3,4-tetrahydronaphthalene;(S)-2-(Diphenylphosphino)-1-phenylethanaMiniuM tetrafluoroborate;(S)-8-(Diphenylphosphino)-1,2,3,4-tetrahydronaphthalen-1-aMiniuM tetrafluoroborate;2-(Diphenylphosphino)ethanaMiniuM tetrafluoroborate;2-[(11bR)-3,5-dihydro-4H-dinaphtho[2,1-c:1',2'-e]phosphepin-4-yl]ethaMiniuM tetrafluorborate;2-[(11bS)-3,5-dihydro-4H-dinaphtho[2,1-c:1',2'-e]phosphepin-4-yl]ethaMiniuM tetrafluorborate;Bis{2-[(11bR)-3,5-dihydro-4H-dinaphtho[2,1-c:1',2'-e]phosphepin-4-yl]ethyl}aMine
• CAS NO: 36953-40-9
• Molecular Formula: C₅H₄BrNO
• Molecular Weight: 174
• EINECS: 214-589-6
• Product Categories: Heterocycle-Pyridine series;Pyridine Series;Pyridines
• Mol File: 36953-40-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 173 °C(Solv: water (7732-18-5))
• Boiling Point: 425.038 °C at 760 mmHg
• Flash Point: 210.856 °C
• Appearance: /
• Density: 1.789 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.614
• Solubility: soluble in Methanol
• PKA: 7.94±0.10(Predicted)
• CAS DataBase Reference: 2-BROMO-4-HYDROXYPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4-HYDROXYPYRIDINE(36953-40-9)
• EPA Substance Registry System: 2-BROMO-4-HYDROXYPYRIDINE(36953-40-9)

Safety Data

• Hazardous Substances Data: 36953-40-9(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow Cryst

InChI:InChI=1/C5H4BrNO/c6-5-3-4(8)1-2-7-5/h1-3H,(H,7,8)

Upstream product

• 357927-50-5 2-bromo-4-fluoro-pyridine 

Downstream Products

• 220585-13-7 4-benzyloxy-2-bromo-pyridine 
• 1142194-85-1 2-bromo-4-cyclopentyloxy-pyridine 
• 89488-29-9 2-bromo-4-methoxypyridine 
• 1098093-40-3 C₁₅H₁₅F₂NO 
• 1415660-34-2 2-bromo-4-butoxypyridine 
• 1206972-19-1 4-(difluoromethoxy)pyridin-2-amine 

Relevant articles and documents

One-step hydroxylation of aryl and heteroaryl fluorides using mechanochemistry

Simple use of KOH allows the direct F to OH exchange of aromatic and heteroaromatic substrates under mechanochemical conditions. The reaction is performed in the absence of solvent with potassium hydroxide as OH source. As a result, this approach is both more atom economical and environmentally friendly than previously described methods for this transformation.