37021-14-0

Basic information

• Product Name: 3-ethyl-1-phenyl-2-thioxoimidazolidin-4-one
• Synonyms: 3-ethyl-1-phenyl-2-thioxoimidazolidin-4-one;3-Ethyl-1-phenyl-2-thioxo-4-imidazolidinone;3-Ethyl-1-phenyl-2-thiohydantoin, 95%
• CAS NO: 37021-14-0
• Molecular Formula: C₁₁H₁₂N₂OS
• Molecular Weight: 220.29078
• EINECS: 253-310-5
• Mol File: 37021-14-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 310.7°Cat760mmHg
• Flash Point: 141.7°C
• Appearance: /
• Density: 1.3g/cm³
• Vapor Pressure: 0.000591mmHg at 25°C
• Refractive Index: 1.666
• CAS DataBase Reference: 3-ethyl-1-phenyl-2-thioxoimidazolidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ethyl-1-phenyl-2-thioxoimidazolidin-4-one(37021-14-0)
• EPA Substance Registry System: 3-ethyl-1-phenyl-2-thioxoimidazolidin-4-one(37021-14-0)

Safety Data

• Hazardous Substances Data: 37021-14-0(Hazardous Substances Data)

Usage

Description

3-ethyl-1-phenyl-2-thioxoimidazolidin-4-one, also known as Eptifibatide, is a synthetic cyclic heptapeptide that belongs to the class of antiplatelet drugs. It is characterized by its ability to inhibit platelet aggregation, making it a crucial component in the management of various cardiovascular conditions.

Uses

Used in Cardiovascular Medicine:
Eptifibatide is utilized as an antiplatelet agent for the prevention of blood clots in patients afflicted with acute coronary syndromes. Its application is particularly relevant in high-risk scenarios, such as during percutaneous coronary intervention procedures, where the risk of thrombotic events is significantly elevated.
The mechanism of action involves the blocking of the glycoprotein IIb/IIIa receptor on platelets, which is instrumental in preventing platelets from aggregating and forming clots. This action is vital in maintaining blood flow and preventing the occlusion of blood vessels that can lead to life-threatening conditions such as heart attacks and strokes.
Eptifibatide is administered intravenously, allowing for a rapid onset of action, which is crucial in emergency situations where swift intervention is necessary to prevent further complications. Its effectiveness in managing platelet aggregation and reducing the risk of thrombotic events makes it a valuable asset in the field of cardiovascular medicine.

InChI:InChI=1/C11H12N2OS/c1-2-12-10(14)8-13(11(12)15)9-6-4-3-5-7-9/h3-7H,2,8H2,1H3

Upstream product

• 2216-92-4 N-phenylglycine ethyl ester 
• 542-85-8 Ethyl isothiocyanate 

Downstream Products

• 114280-13-6 3-ethyl-5-[2-(3-methyl-3H-benzothiazol-2-ylidene)-cyclopentyLiDene]-1-phenyl-2-thioxo-imidazolidin-4-one 
• 101288-67-9 5-cyclopentylidene-3-ethyl-1-phenyl-2-thioxo-imidazolidin-4-one 
• 101782-94-9 3-ethyl-5-(1-ethyl-1H-[4]pyridylidene)-1-phenyl-2-thioxo-imidazolidin-4-one 

Relevant articles and documents

Pesticidal thiohydantoin compositions

The invention describes a method for inhibiting the growth of pests comprising applying thereto a pesticidal amount of a compound of the formula STR1 wherein R1, and R2 are independently hydrogen, substituted or unsubstituted lower alkyl, cycloalkyl, phenyl, or alkenyl, and halogen, amino or hydroxy groups, R3 and R4 are independently hydrogen or substituted or unsubstituted lower alkyl, R5 is hydrogen, substituted or unsubstituted lower alkyl, cycloalkyl or phenyl, and naphthyl groups; pesticidal compositions containing at least one of said compounds; and novel thiohydantoin compounds having pesticidal activity.