371114-60-2

Basic information

• Product Name: {4-[5-(5-tert-butyl-oxazol-2-ylmethylsulfanyl)-thiazol-2-ylcarbamoyl]-cyclohexyl}-carbamic acid tert-butyl ester
• Synonyms: {4-[5-(5-tert-butyl-oxazol-2-ylmethylsulfanyl)-thiazol-2-ylcarbamoyl]-cyclohexyl}-carbamic acid tert-butyl ester
• CAS NO: 371114-60-2
• Molecular Weight: 494.679
• Mol File: 371114-60-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {4-[5-(5-tert-butyl-oxazol-2-ylmethylsulfanyl)-thiazol-2-ylcarbamoyl]-cyclohexyl}-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {4-[5-(5-tert-butyl-oxazol-2-ylmethylsulfanyl)-thiazol-2-ylcarbamoyl]-cyclohexyl}-carbamic acid tert-butyl ester(371114-60-2)
• EPA Substance Registry System: {4-[5-(5-tert-butyl-oxazol-2-ylmethylsulfanyl)-thiazol-2-ylcarbamoyl]-cyclohexyl}-carbamic acid tert-butyl ester(371114-60-2)

Safety Data

• Hazardous Substances Data: 371114-60-2(Hazardous Substances Data)

Upstream product

• 130309-46-5 trans-4-(tert-butoxycarbonylamino)cyclohexane carboxylic acid 
• 224436-97-9 2-amino-5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-thiazole 
• 1776-53-0 4-aminocyclohexanecarboxylic acid 
• 76779-98-1 1-azido-3,3-dimethyl-2-butanone 
• 24424-99-5 di-tert-butyl dicarbonate 
• 5469-26-1 1-Bromopinacolon 
• 33119-72-1 1-amino-3,3-dimethylbutan-2-one hydrochloride 
• 224441-73-0 2-(chloromethyl)-5-t-butyloxazole 
• 333389-44-9 α-N-2-(chloroacetylamino)pinacolone 

Relevant articles and documents

N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl] -4-piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent

N-Acyl-2-aminothiazoles with nonaromatic acyl side chains containing a basic amine were found to be potent, selective inhibitors of CDK2/cycE which exhibit antitumor activity in mice. In particular, compound 21 {N-[5-[[[5-(1,1-dimethylethyl)-2- oxazolyl]m