37141-71-2

Basic information

• Product Name: 1H-Pyrazole-5-carbonyl chloride, 1,3-dimethyl-4-nitro-
• CAS NO: 37141-71-2
• Molecular Formula: C6H6ClN3O3
• Molecular Weight: 203.585
• Mol File: 37141-71-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-5-carbonyl chloride, 1,3-dimethyl-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-5-carbonyl chloride, 1,3-dimethyl-4-nitro-(37141-71-2)
• EPA Substance Registry System: 1H-Pyrazole-5-carbonyl chloride, 1,3-dimethyl-4-nitro-(37141-71-2)

Safety Data

• Hazardous Substances Data: 37141-71-2(Hazardous Substances Data)

Upstream product

• 3920-37-4 1,3-dimethyl-4-nitro-1H-pyrazole-5-carboxylic acid 

Downstream Products

• 78208-58-9 1,3-dimethyl-4-nitropyrazole-5-carboxamide 
• 868392-50-1 4-amino-N,1,3-trimethyl-N-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1H-pyrazole-5-carboxamide 
• 104393-45-5 4-(1,3-dimethyl-7-oxopyrazolo<4,3-d>pyrimidin-5-yl)-N-<2-(dimethylamino)ethyl>benzenesulfonamide 
• 104393-36-4 5-(2-Chloro-4-nitro-phenyl)-1,3-dimethyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one 
• 104393-34-2 4-(1,3-dimethyl-7-oxopyrazolo<4,3-d>pyrimidin-5-yl)benzenesulfonic acid 
• 104393-52-4 4-(3,5-Dimethoxy-benzoylamino)-2,5-dimethyl-2H-pyrazole-3-carboxylic acid amide 
• 104393-35-3 1,3-Dimethyl-5-(4-trifluoromethyl-phenyl)-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one 
• 104393-33-1 5-(2,4-Dimethoxy-phenyl)-1,3-dimethyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one 
• 104393-51-3 4-(3,4-Dichloro-benzoylamino)-2,5-dimethyl-2H-pyrazole-3-carboxylic acid amide 
• 104393-50-2 4-(2-Methoxy-benzoylamino)-2,5-dimethyl-2H-pyrazole-3-carboxylic acid amide 
• 104393-32-0 5-(3,4-Dimethoxy-phenyl)-1,3-dimethyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one 
• 104393-27-3 5-(3,5-Dimethoxy-phenyl)-1,3-dimethyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one 
• 104393-41-1 5-(2-Amino-4-chloro-phenyl)-1,3-dimethyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one 
• 104393-48-8 4-(4-Chloro-benzoylamino)-2,5-dimethyl-2H-pyrazole-3-carboxylic acid amide 

Relevant articles and documents

N-7 SUBSTITUTED PURINE AND PYRAZOLOPYRIMINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE

The present invention relates to compounds of Formula I: wherein R1, R2, R3, A1, A2, A3, A4, Y1 and Y2 and D have the meaning described herein. The present invention also relates to pharmaceutical compositions comprising such compounds and therapeutic uses thereof.

Synthesis and Structure-Activity Relationships of Pyrazolopyrimidin-7-ones as Adenosine Receptor Antagonists

A series of 21 1,3-dialkylpyrazolopyrimidin-7-ones substituted in the 5-position with various phenyl substituents has been synthesized and found to have affinity for the adenosine A1 receptor.The potency pattern due to substituents of the phenyl ring was found to parallel that found in a previously reported 1,3-dialkyl-8-phenylxanthine series.A quantitative structure-activity relationship was developed between these two series that correctly predicted the potencies of six additional 5-substituted pyrazolopyrimidines that were synthesized during the course of the analysis.With use of the correlation as a guide, one additional 5-phenylpyrazolopyrimidine containing a 4amino>sulfonyl substituent to improve aqueous solubility was prepared.On the basis of the high correlation between adenosine binding affinities of analogously substituted xanthines and pyrazolopyrimidines and the close superposition of the heterocyclic rings and substituents that is apparent from molecular models of these two series (Figure 2), it is hypothesized they fit the receptor in an analogous fashion.