374675-21-5 Usage
Description
KISSPEPTIN-10, also known as Metastin (45-54), is a 10 amino acid peptide that corresponds to the bioactive C-terminal 45-54 amino acids of metastin, a metastasis suppressor gene product. It acts as a potent agonist of GPR54 (OT7T175, AXOR12), with approximately 8-fold higher binding affinity than metastin (Ki values of 0.042 and 0.34 nM, respectively, for displacement of metastin (40-54)). KISSPEPTIN-10 induces calcium mobilization in GPR54-transfected cells (EC50 = 0.18-1.1 nM) and inhibits the migration of GPR54-transfected CHO cells at concentrations of 10-100 nM, equaling the potency of full-length metastin.
Used in Pharmaceutical Industry:
KISSPEPTIN-10 is used as a potent and selective agonist of AXOR12 and hOT7T175 for the development of drugs targeting the GPR54 receptor, which plays a crucial role in the regulation of reproductive functions and has potential therapeutic applications in various diseases.
Used in Reproductive Research:
KISSPEPTIN-10 is used as a research tool for studying the role of GPR54 in the regulation of reproductive functions, including the release of progesterone from MA-10 cells and the induction of gonadal differentiation in clownfish. This helps researchers understand the underlying mechanisms of reproductive processes and develop potential therapeutic interventions for reproductive disorders.
Biochem/physiol Actions
Metastin functions as a tumor suppressor via inhibiting secondary tumor growth. Activation of KISS1R (KISS1 receptor), upon binding KISS1, enhances intracellular calcium and activates MAPKs, which restricts cell motility and proliferation. Metastin acts as a potential therapeutic target for various cancers including melanoma, thyroid cancer and bladder cancer, squamous cell carcinoma of the esophagus gastric cancer, hepatocellular carcinoma and breast cancer. Metastin has a crucial role in reproduction. It regulates hypothalamic-pituitary-gonadal axis role via controlling gonadotropin-releasing hormone (GnRH) secretion and determines the onset of puberty. Mutation of the gene leads to central precocious puberty (CPP) in male and dysfunction of metastin signaling causes isolated hypogonadotropic hypogonadism (IHH) in humans and mice. Metastin has the ability to enhance the?plasma levels?of?gonadotropins (follicle-stimulating hormone and luteinizing hormone) and stimulate ovulation?in prepubertal female rats.
Check Digit Verification of cas no
The CAS Registry Mumber 374675-21-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,4,6,7 and 5 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 374675-21:
(8*3)+(7*7)+(6*4)+(5*6)+(4*7)+(3*5)+(2*2)+(1*1)=175
175 % 10 = 5
So 374675-21-5 is a valid CAS Registry Number.
