374725-03-8

Basic information

• Product Name: tert-butyl 3-oxo-1-phenylpropylcarbamate
• Synonyms: tert-butyl 3-oxo-1-phenylpropylcarbamate
• CAS NO: 374725-03-8
• Molecular Weight: 249.31
• Mol File: 374725-03-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: tert-butyl 3-oxo-1-phenylpropylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-oxo-1-phenylpropylcarbamate(374725-03-8)
• EPA Substance Registry System: tert-butyl 3-oxo-1-phenylpropylcarbamate(374725-03-8)

Safety Data

• Hazardous Substances Data: 374725-03-8(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 91230-12-5 (1-phenyl-allyl)-carbamic acid tert-butyl ester 
• 4393-21-9 1-(phenyl)allylamine 
• 51479-71-1 O-(3-Phenyl-2-propenyl)-2,2,2-Trichlorethanimidsaeure-O-(3-phenyl-2-propenyl)ester 
• 104-54-1 3-Phenylpropenol 
• 59874-90-7 N-<1-(1-phenylprop-2-enyl)> trichloroacetamide 
• 218449-48-0 (3-hydroxy-1-phenylpropyl)carbamate tert-butyl ester 
• 257861-50-0 3-tert-butoxycarbonylamino-3-phenylpropionic acid methyl ester 
• 4383-23-7 1-phenyl-but-3-enylamine 
• 187974-79-4 (±)-tert-butyl (1-phenylbut-3-en-1-yl)carbamate 

Downstream Products

• 1114997-58-8 tert-butyl [3-(4-(7-chloroquinolin-4-yl)piperazin-1-yl)-1-phenylpropyl]carbamate 
• 718611-17-7 S-(3-hydroxy-1-phenyl-propyl)-carbamic acid tert-butyl ester 
• 1192966-53-2 tert-butyl (1-phenylbut-3-yn-1-yl)carbamate 
• 83649-47-2 (S)-(-)-β-Phenyl-β-alanine hydrochloride 
• 14676-01-8 3-(tert-butoxycarbonylamino)-3-phenylpropanoic acid 

Relevant articles and documents

Palladium-catalyzed anti-markovnikov oxidation of allylic amides to protected β-amino aldehydes

A general method for the preparation of N-protected β-amino aldehydes from allylic amines or linear allylic alcohols is described. Here the Pd(II)-catalyzed oxidation of N-protected allylic amines with benzoquinone is achieved in tBuOH under ambient conditions with excellent selectivity toward the anti-Markovnikov aldehyde products and full retention of configuration at the allylic carbon. The method shows a wide substrate scope and is tolerant of a range of protecting groups. Furthermore, β-amino aldehydes can be obtained directly from protected allylic alcohols via palladium-catalyzed autotandem reactions, and the application of this method to the synthesis of β-peptide aldehydes is described. From a mechanistic perspective, we demonstrate that tBuOH acts as a nucleophile in the reaction and that the initially formed tert-butyl ether undergoes spontaneous loss of isobutene to yield the aldehyde product. Furthermore, tBuOH can be used stoichiometrically, thereby broadening the solvent scope of the reaction. Primary and secondary alcohols do not undergo elimination, allowing the isolation of acetals, which subsequently can be hydrolyzed to their corresponding aldehyde products.

ALPHA2B AND ALPHA2C AGONISTS

Described herein are compounds that can be useful as bioactive agents. More specifically, the compounds described herein can be useful as both α2B and α2C adrenergic agonists. Methods of synthesis and administration of the compounds are also disclosed.

Discovery of a novel CCR5 antagonist lead compound through fragment assembly

CCR5, as the major co-receptor for HIV-1 entry, is an attractive novel target for the pharmaceutical industry in the HIV-1 therapeutic area. In this study, based on the structures of maraviroc and 1,4-bis(4-(7-chloroquinolin-4- yl)piperazin-1-yl)butane-1,4-dione (1), which was identified using structure-based virtual screening in conjunction with a calcium mobilization assay, a series of novel small molecule CCR5 antagonists have been designed and synthesized through fragment assembly. Preliminary SARs were obtained, which are in good agreement with the molecular binding model and should prove helpful for future antagonist design. The novel scaffold presented here might also be useful in the development of maraviroc-derived second generation CCR5 antagonists.