374756-60-2

Basic information

• Product Name: 4-Iodo-3,5-dimethyl-1-(2,4,6-trimethylbenzoyl)-1H-pyrazole
• Synonyms: 4-Iodo-3,5-dimethyl-1-(2,4,6-trimethylbenzoyl)-1H-pyrazole
• CAS NO: 374756-60-2
• Molecular Weight: 368.217
• Mol File: 374756-60-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Iodo-3,5-dimethyl-1-(2,4,6-trimethylbenzoyl)-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Iodo-3,5-dimethyl-1-(2,4,6-trimethylbenzoyl)-1H-pyrazole(374756-60-2)
• EPA Substance Registry System: 4-Iodo-3,5-dimethyl-1-(2,4,6-trimethylbenzoyl)-1H-pyrazole(374756-60-2)

Safety Data

• Hazardous Substances Data: 374756-60-2(Hazardous Substances Data)

Upstream product

• 480-63-7 mesitylenecarboxylic acid 
• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 2033-45-6 4-iodo-3,5-dimethyl-1H-pyrazole 
• 938-18-1 mesitylene-2-carboxylic acid chloride 

Downstream Products

• 374756-66-8 2-{3-[3,5-Dimethyl-1-(2,4,6-trimethylbenzoyl)-1H-pyrazol-4-yl]-prop-2-ynyloxy}isoindole-1,3-dione 
• 592509-07-4 O-{3-[3,5-Dimethyl-1-(2,4,6-trimethylbenzoyl)-1H-pyrazol-4-yl]-prop-2-ynyl}hydroxylamine 
• 374756-63-5 3-[3,5-Dimethyl-1-(2,4,6-trimethylbenzoyl)-1H-pyrazol-4-yl]-prop-2-yn-1-ol 

Relevant articles and documents

O-pyrazolylpropynyl-hydroxylamines as versatile intermediates in the synthesis of compounds of pharmacological interest

Through an optimised Pd/Cu-catalysed cross-coupling reaction of 4-iodopyrazoles with 2-propyn-1-ol, followed by Mitsunobu transformation with N-hydroxyphthalimide and subsequent hydrazinolysis, O-[(pyrazol-4-yl)-prop-2-ynyl]-hydroxylamines were obtained in good yields. Their usefulness as intermediates in the synthesis of pharmaceuticals is exemplified by the first reported intramolecular cyclization of O-(2-propynyl)-hydroxylamines to yield 4,5-dihydro-isoxazoles.