37492-24-3

Basic information

• Product Name: 20-ETHYL PROSTAGLANDIN E2
• Synonyms: 9-OXO-11ALPHA,15S-DIHYDROXY-20A,20B-DIHOMOPROSTA-5Z,13E-DIEN-1-OIC ACID;20-ETHYL PROSTAGLANDIN E2;NXMMZTNQIJBMBC-QKIVIXBWSA-N
• CAS NO: 37492-24-3
• Molecular Formula: C22H36O5
• Molecular Weight: 380.52
• Mol File: 37492-24-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 20-ETHYL PROSTAGLANDIN E2(CAS DataBase Reference)
• NIST Chemistry Reference: 20-ETHYL PROSTAGLANDIN E2(37492-24-3)
• EPA Substance Registry System: 20-ETHYL PROSTAGLANDIN E2(37492-24-3)

Safety Data

• Hazardous Substances Data: 37492-24-3(Hazardous Substances Data)

Usage

Description

20-Ethyl Prostaglandin E2 (20-ethyl PGE2) is an analog of Prostaglandin E2 (PGE2) with an extended ω-chain by the addition of two methylene carbon atoms. This structural modification differentiates it from other prostaglandin analogs like unoprostone, which has lower side chain modifications that limit its affinity for FP receptors. 20-ethyl PGE2 retains the natural 15(S) allylic hydroxyl in the lower side chain, potentially enhancing its potency. E-type prostaglandins, including 20-ethyl PGE2, are known for their diverse effects, such as inflammatory and cytoprotective properties.

Uses

Used in Pharmaceutical Industry:
20-Ethyl Prostaglandin E2 is used as a potential therapeutic agent for various conditions due to its inflammatory and cytoprotective effects. Its structural similarity to PGE2 allows it to potentially modulate biological processes and provide therapeutic benefits in treating specific diseases.
Used in Research Applications:
In the field of medical and biological research, 20-ethyl PGE2 serves as an important tool for studying the roles and interactions of prostaglandins in cellular processes. Its unique structural features make it a valuable compound for investigating the mechanisms of action and receptor binding profiles of prostaglandin analogs.
Used in Ophthalmology:
As an analog of PGE2, 20-ethyl Prostaglandin E2 may be used as a potential treatment for glaucoma, similar to unoprostone, which is clinically approved for this purpose. Its extended ω-chain and retained natural 15(S) allylic hydroxyl could potentially offer improved potency and efficacy in managing intraocular pressure.
Used in Inflammation Management:
Given the known inflammatory effects of E-type prostaglandins, 20-ethyl PGE2 could be utilized in the development of anti-inflammatory drugs or therapies, targeting conditions where inflammation plays a significant role in disease progression.
Used in Drug Development:
The unique structural features of 20-ethyl PGE2 make it a promising candidate for the development of new drugs with improved potency and selectivity for specific prostanoid receptors. This could lead to the creation of more effective medications for a range of conditions, including those involving inflammation, pain, and other prostaglandin-mediated processes.