375-85-9

Basic information

• Product Name: Perfluoroheptanoic acid
• Synonyms: perfluoroheptanoic;perfluoro-n-heptanoicacid;tridecafluoro-heptanoicaci;N-TRIDECAFLUOROHEPTANOIC ACID;N-PERFLUOROHEPTANOIC ACID;PERFLUOROENANTHIC ACID;PERFLUOROHEPTANOIC ACID;PFHPA
• CAS NO: 375-85-9
• Molecular Formula: C₇HF₁₃O₂
• Molecular Weight: 364.06
• EINECS: 206-798-9
• Product Categories: Analytical Chemistry;Ion-Pair Reagents for HPLC;LC/MS Ion-Pair Reagents for Basic Samples;Fluorous Chemistry;Fluorous Compounds;Synthetic Organic Chemistry;organofluorine compounds
• Mol File: 375-85-9.mol
• Article Data: 20

Chemical Properties

• Melting Point: ~30 °C
• Boiling Point: 175 °C742 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear colorless to pale yellow/Liquid After Melting
• Density: 1.792 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.539mmHg at 25°C
• Refractive Index: n20/D 1.306(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.47±0.10(Predicted)
• Water Solubility: Insoluble in water.
• Stability: Stable. Incompatible with strong bases.
• BRN: 1808210
• CAS DataBase Reference: Perfluoroheptanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Perfluoroheptanoic acid(375-85-9)
• EPA Substance Registry System: Perfluoroheptanoic acid(375-85-9)

Safety Data

• Hazard Codes: C
• Statements: 22-34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• TSCA: T
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 375-85-9(Hazardous Substances Data)

Usage

Description

Perfluoroheptanoic acid, also known as PFHpA, perfluoroheptanoic acid, perfluoro-n-heptanoic acid, or tridecafluoro-1-heptanoic acid, is a seven-carbon compound in the perfluoroalkyl family of chemicals. It is a white solid under ambient conditions with a relatively low melting point and can sublime under certain conditions. Perfluoroheptanoic acid is structurally similar to the highly persistent and outlawed PFOA and is known to persist in the environment.

Uses

1. Used in Environmental Applications:
Perfluoroheptanoic acid is used as a persistent environmental pollutant, which can accumulate in human tissues through various exposure routes. It may interfere toxically with the immune system, liver, development, and endocrine systems.
2. Used in Industrial Applications:
Perfluoroheptanoic acid is used as an important organic intermediate in various industries, including agrochemical, pharmaceutical, and dyestuff fields.
3. Used in Consumer Products:
Perfluoroheptanoic acid is used as a component in stainand grease-proof coatings for furniture, carpet, and food packaging.
4. Used in Chemical Research:
Due to its unique chemical properties, Perfluoroheptanoic acid is utilized in chemical research to study the behavior of perfluorinated compounds and their environmental impact.

InChI:InChI=1/C7HF13O2.H3N/c8-2(9,1(21)22)3(10,11)4(12,13)5(14,15)6(16,17)7(18,19)20;/h(H,21,22);1H3

Upstream product

• 626-27-7 n-heptanoic anhydride 
• 559-14-8 perfluorooct-1-ene 
• 111-14-8 oenanthic acid 
• 375-83-7 perfluoro-1H-heptane 
• 335-58-0 perfluoroheptyl iodide 
• 96-49-1 [1,3]-dioxolan-2-one 
• 355-43-1 n-perfluorohexyl iodide 
• 124-38-9 carbon dioxide 
• 20109-59-5 perfluoroheptanoic acid sodium salt 
• 106993-79-7 F-hexyl-1 butyne-1-ol-3 
• 7726-95-6 bromine 
• 7782-50-5 chlorine 
• 335-67-1 Perfluorooctanoic acid 
• 647-42-7 1H,1H,2H,2H-tridecafluoro-n-octanol 

Downstream Products

• 375-82-6 2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-ol 
• 335-54-6 Perfluorhexanamid 
• 52447-22-0 perfluoroheptanoyl chloride 
• 117897-74-2 2,2,3,3,4,4,5,5,6,6,7,7,7-Tridecafluoro-heptanoic acid (4-cyanomethyl-phenyl)-amide 
• 77893-60-8 tridecafluorohexyl-acetone 
• 136909-77-8 Acetic acid 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-1-methyl-octyl ester 
• 136909-82-5 Acetic acid 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-1-methylene-octyl ester 
• 136909-84-7 (Z)-4,5,5,6,6,7,7,8,8,9,9,9-Dodecafluoro-non-3-en-2-one 
• 88950-96-3 2,2,3,3,4,4,5,5,6,6,7,7,7-Tridecafluoro-1-p-tolyl-heptan-1-one 
• 355-37-3 1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluorohexane 
• 375-84-8 2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptanoyl fluoride 
• 119403-54-2 2-(perfluorohexyl)benzimidazole 
• 533-18-6 2-methylphenyl acetate 
• 140-39-6 1-acetoxy-4-methylbenzene 

Relevant articles and documents

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Preparation method of fluorine-containing carboxylic acid

The invention discloses a preparation method of fluorine-containing carboxylic acid. The method comprises the following steps: reacting fluorine-containing carboxylate used as a raw material with an acylating chlorination reagent to obtain a corresponding mixture of fluorine-containing acyl chloride and fluorine-containing anhydride, and hydrolyzing and drying the mixture of fluorine-containing acyl chloride and fluorine-containing anhydride to obtain high-purity fluorine-containing carboxylic acid. The method provided by the invention is suitable for post-treatment of fluorine-containing carboxylic acid prepared by a fluorine-containing olefin (monoolefine, diene, cycloolefin and the like) oxidation method, replaces the traditional strong acid acidification and ether continuous extractionprocess, and is simpler, more convenient and more applicable; and the method can also be used for recovering and purifying a fluorine-containing carboxylate emulsifier. The purity of the fluorine-containing carboxylic acid prepared by the method can reach 98% or above.

The effect of oxygen in the photocatalytic oxidation pathways of perfluorooctanoic acid

The influence of oxygen in the photocatalytic oxidation of perfluorooctanoic acid (PFOA) promoted by a commercial nano-sized titanium dioxide was studied by testing the reaction in different conditions: static air, oxygen flux, nitrogen flux and pre-saturated nitrogen flux. The reaction was monitored by Total Organic Carbon (TOC) analysis and Ionic Chromatography (IC). Shorter chain perfluorocarboxylic acids (PFCAs; Cn, n = 1-7) intermediate degradation products were quantitatively determined by High-Performance Liquid Chromatography combined with Mass Spectrometry (HPLC-MS) analysis. The presence of shorter chain PFCAs in solution was also monitored by 19F NMR. The experimental findings are in agreement with two major oxidative pathways: Cn → Cn-1 photo-redox and β-scissions routes mediated by COF2 elimination. Depending on the experimental conditions, the mutually operating mechanisms could be unbalanced up to the complete predominance of one pathway over the other. In particular, the existence of the β-scissions route with COF2 elimination was corroborated by the isolation and characterization of carbonyl difluoride, a predicted fluorinated decomposition by-product.