3751-48-2 Usage
Description
3-(3-METHYLPHENYL)PROPIONIC ACID, also known as 3-m-Tolylpropanoic Acid, is a white solid organic compound with the molecular formula C10H12O2. It is characterized by its aromatic structure, which includes a methyl group attached to a phenyl ring and a propionic acid functional group. 3-(3-METHYLPHENYL)PROPIONIC ACID is known for its role in the synthesis of various pharmaceutical agents and has potential applications in the medical field.
Uses
Used in Pharmaceutical Synthesis:
3-(3-METHYLPHENYL)PROPIONIC ACID is used as a key intermediate in the synthesis of piperidine antagonists, specifically as CCR1-selective inhibitors. These inhibitors are important in the development of treatments for various inflammatory and autoimmune diseases, as they help regulate the immune response by targeting the CCR1 receptor.
3-(3-METHYLPHENYL)PROPIONIC ACID is also used in the synthesis of small molecule antagonists of the vasoactive intestinal peptide receptor 1 (VIPR1). These antagonists have potential applications in the treatment of various conditions, including asthma, chronic obstructive pulmonary disease (COPD), and other respiratory disorders, as well as certain types of cancer.
In the Chemical Industry:
3-(3-METHYLPHENYL)PROPIONIC ACID can be utilized as a building block for the development of other organic compounds and materials. Its unique structure and functional groups make it a valuable component in the synthesis of various chemicals, including pharmaceuticals, agrochemicals, and specialty chemicals.
In the Research and Development Sector:
Due to its potential applications in the medical field, 3-(3-METHYLPHENYL)PROPIONIC ACID is also used as a research compound in the development of new drugs and therapies. Researchers can leverage its chemical properties to design and synthesize novel molecules with specific biological activities, contributing to the advancement of medical science.
Check Digit Verification of cas no
The CAS Registry Mumber 3751-48-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,7,5 and 1 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 3751-48:
(6*3)+(5*7)+(4*5)+(3*1)+(2*4)+(1*8)=92
92 % 10 = 2
So 3751-48-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H12O2/c1-8-3-2-4-9(7-8)5-6-10(11)12/h2-4,7H,5-6H2,1H3,(H,11,12)
3751-48-2Relevant articles and documents
Photoredox Activation of Formate Salts: Hydrocarboxylation of Alkenes via Carboxyl Group Transfer
Huang, Yan,Hou, Jing,Zhan, Le-Wu,Zhang, Qian,Tang, Wan-Ying,Li, Bin-Dong
, p. 15004 - 15012 (2021/12/14)
A photoredox activation mode of formate salts for carboxylation was developed. Using a formate salt as the reductant, carbonyl source, and hydrogen atom transfer reagent, a wide range of alkenes can be converted into acid products via a carboxyl group tra
Synthesis method of succinic acid derivative or 3 -arylpropionic acid (by machine translation)
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Paragraph 0101-0114; 0115; 0129, (2020/10/30)
The invention discloses a synthesis method of a succinic acid derivative or 3 -arylpropionic acid, which comprises the following steps: adding a base in a drying reaction tube and CO removing CO. 2 The reaction is carried out under the irradiation of visible light, the reaction is carried out under visible light irradiation, and then separation and purification are carried out to obtain the butanedioic acid derivative or 3 -arylpropionic acid product; the base comprises sodium tert-butoxide, potassium tert-butoxide, lithium tert-butyl alcohol and 4 - potassium carbonate; and the reaction substrate comprises an acrylate compound or an aryl vinyl compound. CO can be induced by visible light. 2 The scheme provided by the invention is mild in reaction condition and wide in reaction 3 - substrate selectivity, and the reaction substrate is wide in selectivity, the raw materials are cheap and easily available, and the method has a good industrial application prospect. (by machine translation)
Site-Selective, Remote sp3 C?H Carboxylation Enabled by the Merger of Photoredox and Nickel Catalysis
Sahoo, Basudev,Bellotti, Peter,Juliá-Hernández, Francisco,Meng, Qing-Yuan,Crespi, Stefano,K?nig, Burkhard,Martin, Ruben
supporting information, p. 9001 - 9005 (2019/06/24)
A photoinduced carboxylation of alkyl halides with CO2 at remote sp3 C?H sites enabled by the merger of photoredox and Ni catalysis is described. This protocol features a predictable reactivity and site selectivity that can be modulated by the ligand backbone. Preliminary studies reinforce a rationale based on a dynamic displacement of the catalyst throughout the alkyl side chain.
