37585-16-3

Basic information

• Product Name: 2-AMINO-4-CHLORO-BENZENEMETHANOL
• Synonyms: 2-AMINO-4-CHLORO-BENZENEMETHANOL;(2-AMino-4-chloro-phenyl)-Methanol;2-Amino-4-chlorobenzyl alcohol
• CAS NO: 37585-16-3
• Molecular Formula: C₇H₈ClNO
• Molecular Weight: 157.6
• Mol File: 37585-16-3.mol
• Article Data: 41

Chemical Properties

• Melting Point: 138-142°C
• Boiling Point: 324.2±27.0 °C(Predicted)
• Appearance: /
• Density: 1.341±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 14.01±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-4-CHLORO-BENZENEMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-CHLORO-BENZENEMETHANOL(37585-16-3)
• EPA Substance Registry System: 2-AMINO-4-CHLORO-BENZENEMETHANOL(37585-16-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-43
• Safety Statements: 26-36/37
• WGK Germany: 3
• Hazardous Substances Data: 37585-16-3(Hazardous Substances Data)

Usage

General Description

2-Amino-4-chloro-benzenemethanol, also known as 4-chloro-2-aminophenylmethanol, is a chemical compound with the molecular formula C7H8ClNO. It is a benzene derivative with a chlorine atom and an amino group attached to the benzene ring. 2-AMINO-4-CHLORO-BENZENEMETHANOL is commonly used in the synthesis of pharmaceuticals and organic compounds. It possesses important properties such as anti-inflammatory and anti-cancer activities, making it a valuable building block in drug discovery and development. Its versatile nature and pharmacological potential make it a crucial intermediate in the field of medicinal chemistry.

Upstream product

• 22996-18-5 (4-chloro-2-nitrophenyl)methanol 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 7440-06-4 platinum 
• 60064-34-8 2-Carboethoxy-5-chloroaniline 

Downstream Products

• 1026433-37-3 Phenyl-acetic acid 4-chloro-2-phenylacetylamino-benzyl ester 
• 183173-37-7 N-(5-Chloro-2-hydroxymethyl-phenyl)-2,2,2-trifluoro-acetamide 
• 150097-78-2 2-(Benzylcarbonylamino)-4-chloro benzaldehyde 
• 150097-77-1 N-(Benzylcarbonyl)-5-chloro-2-hydroxymethylaniline 
• 150097-66-8 7-chloro-4-(2-cyanoethyl)-3-phenyl-quinolin-2(1H)-one 
• 150097-63-5 4-(2-carboxyethyl)-7-chloro-3-phenyl-2(1H)-quinolone 
• 150097-65-7 4-(2-aminocarbonylethyl)-7-chloro-3-phenyl-2(1H)-quinolone 
• 150097-64-6 7-chloro-4-(2-methoxycarbonylethyl)-3-phenyl-2(1H)-quinolone 
• 150097-81-7 7-chloro-4-[(2-ethoxycarbonyl)ethyl]-3-phenyl-2(1H)-quinolone 
• 150097-80-6 4-(4-Chloro-2-phenylacetylamino-phenyl)-4-oxo-butyric acid ethyl ester 
• 150097-79-3 4-(4-Chloro-2-phenylacetylamino-phenyl)-4-hydroxy-butyric acid ethyl ester 
• 183173-45-7 N-(2-Bromomethyl-5-chloro-phenyl)-2,2,2-trifluoro-acetamide 
• 150869-44-6 N-[5-chloro-2-(hydroxymethyl)phenyl]acetamide 
• 147778-03-8 N-[5-chloro-2-(chloromethyl)phenyl]acetamide 

Relevant articles and documents

Synthesis of 3,1-Benzoxazines, 3,1-Benzothiazines and 3,1-Benzoxazepines via N-Arylimino-1,2,3-dithiazoles

o-Aminobenzyl alcohols are converted in two steps into 3,1-benzoxazines 7 and 3,1-benzothiazines 8, and o-aminophenethyl alcohol is converted into 3,1-benzoxazepine 9.

Access to 5,6-Spirocycles Bearing Three Contiguous Stereocenters via Pd-Catalyzed Stereoselective [4 + 2] Cycloaddition of Azadienes

We present herein a highly diastereo- and enantioselective Pd-catalyzed [4 + 2] cycloaddition of benzofuran-derived azadienes with vinyl benzoxazinanones, which represents a rare highly stereoselective cycloaddition of this class of fused azadienes as a two-atom synthon. The use of a phosphoramidite ligand bearing a chiral secondary amine with a simple biphenyl backbone proved to be the key to construct the novel spirocyclic tetrahydroquinoline scaffold containing three contiguous stereocenters as a single diastereomer in high enantioselectivity.

A Convenient Formal [4+2] Heterocylization Route to Bis(triflyl)tetrahydroquinolines

We report the sustainable and efficient synthesis of a new type of quinoline derivatives bearing one or two SO2CF3 groups. The protocol is metal-, catalyst- and irradiation-free, involves the use of readily available and stable precursors, and avoids the formation of side products. Also, the mild conditions of the process allow the tolerance of a wide range of functional groups.