37617-33-7Relevant articles and documents
An OPAA enzyme mutant with increased catalytic efficiency on the nerve agents sarin, soman, and GP
Bae, Sue Y.,Myslinski, James M.,McMahon, Leslie R.,Height, Jude J.,Bigley, Andrew N.,Raushel, Frank M.,Harvey, Steven P.
, p. 65 - 71 (2018)
The wild-type OPAA enzyme has relatively high levels of catalytic activity against several organophosphate G-type nerve agents. A series of mutants containing replacement amino acids at the OPAA Y212, V342, and I215 sites showed several fold enhanced catalytic efficiency on sarin, soman, and GP. One mutant, Y212F/V342L, showed enhanced stereospecificity on sarin and that enzyme along with a phosphotriesterase mutant, GWT, which had the opposite stereospecificity, were used to generate enriched preparations of each sarin enantiomer. Inhibition of acetylcholinesterase by the respective enantioenriched sarin solutions subsequently provided identification of the sarin enantiomers as separated by normal phase enantioselective liquid chromatography coupled with atmospheric pressure chemical ionization–mass spectrometry.
Asymmetric hydrogenation of tert-alkyl ketones: DMSO effect in unification of stereoisomeric ruthenium complexes
Yamamura, Tomoya,Nakatsuka, Hiroshi,Tanaka, Shinji,Kitamura, Masato
supporting information, p. 9313 - 9315 (2013/09/12)
Face off: The ruthenium complexes of a new axially chiral PNNligand (L) are highly efficient in the presence of dimethylsulfoxide (DMSO) for hydrogenation of both functionalized and unfunctionalized tert-alkyl ketones. DMSO is thought to narrow down the many possible complex stereoisomers into a single facial L/Ru complex, thus enhancing the reactivity, selectivity, and productivity. Copyright
The scope and limitations of 1,3-stannyl shift-promoted intramolecular cyclizations of α-stannyl radicals with a formyl group
Ueng, Shau-Hua,Chen, Ming-Jen,Chu, Shu-Fang,Shao, Yar-Fang,Fan, Gang-Ting,Chang, Sheng-Yueh,Tsai, Yeun-Min
, p. 1502 - 1512 (2007/10/03)
α-Tributylstannyl radicals can be generated from the corresponding bromides or xanthates. These radicals undergo efficient intramolecular 1,5-cyclizations with a formyl group. The resulting β-stannyl alkoxy radicals proceed through a 1,3-stannyl shift fro