376584-79-1Relevant articles and documents
Design and synthesis of highly potent benzodiazepine γ-secretase inhibitors: Preparation of (2S,3R)-3-(3,4- difluorophenyl)-2-(4-fluorophenyl)-4-hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of an as
Churcher, Ian,Williams, Susie,Kerrad, Sonia,Harrison, Timothy,Castro, José L.,Shearman, Mark S.,Lewis, Huw D.,Clarke, Earl E.,Wrigley, Jonathan D. J.,Beher, Dirk,Tang, Yui S.,Liu, Wensheng
, p. 2275 - 2278 (2003)
Novel benzodiazepine-containing γ-secretase inhibitors for potential use in Alzheimer's disease have been designed that incorporate a substituted hydrocinnamide C-3 side chain. A syn combination of α-alkyl or aryl and β-hydroxy or hydroxymethyl substituen
