37662-05-8

Basic information

• Product Name: Acetic acid, 2-[[(1R)-1-phenylethyl]iMino]-, ethyl ester
• Synonyms: Acetic acid, 2-[[(1R)-1-phenylethyl]iMino]-, ethyl ester;Ethyl D-(α-MethylbenzyliMino)acetate
• CAS NO: 37662-05-8
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.253
• Mol File: 37662-05-8.mol
• Article Data: 31

Chemical Properties

• Appearance: /
• Solubility: DCM
• CAS DataBase Reference: Acetic acid, 2-[[(1R)-1-phenylethyl]iMino]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, 2-[[(1R)-1-phenylethyl]iMino]-, ethyl ester(37662-05-8)
• EPA Substance Registry System: Acetic acid, 2-[[(1R)-1-phenylethyl]iMino]-, ethyl ester(37662-05-8)

Safety Data

• Hazardous Substances Data: 37662-05-8(Hazardous Substances Data)

Usage

Description

Acetic acid, 2-[[(1R)-1-phenylethyl]iMino]-, ethyl ester, also known as Ethyl D-(α-Methylbenzylimino)acetate, is an organic compound that serves as an intermediate in the synthesis of pharmaceuticals. It is characterized by its unique chemical structure, which includes an imino group and an ethyl ester group, making it a versatile building block in organic chemistry.

Uses

Used in Pharmaceutical Industry:
Acetic acid, 2-[[(1R)-1-phenylethyl]iMino]-, ethyl ester is used as an intermediate in the preparation of Argatroban (A769000), a direct thrombin inhibitor. Argatroban is a medication used to treat and prevent blood clots in patients with heparin-induced thrombocytopenia (HIT), a rare but serious complication of heparin therapy. Acetic acid, 2-[[(1R)-1-phenylethyl]iMino]-, ethyl ester's role in the synthesis of Argatroban highlights its importance in the development of life-saving medications.

Upstream product

• 924-44-7 glyoxylic acid ethyl ester 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 64805-08-9 ethyl glyoxylate hydrate 

Downstream Products

• 139405-46-2 (2R,6R)-1-<(R)-1-phenylethyl>-6-ethoxycarbonyl-2-methyl-3,4-didehydropiperidine 
• 134984-67-1 (2S,6S)-1-<(R)-1-phenylethyl>-6-ethoxycarbonyl-2-methyl-3,4-didehydropiperidine 
• 134984-66-0 (2S,5R,6S)-1-<(R)-1-phenylethyl>-6-ethoxycarbonyl-2,5-dimethyl-3,4-didehydropiperidine 
• 139405-45-1 (2R,5S,6R)-1-<(R)-1-phenylethyl>-6-ethoxycarbonyl-2,5-dimethyl-3,4-didehydropiperidine 
• 134984-63-7 (1S,3S,4R)-2-((R)-1-phenyl-ethyl)-2-aza-bicyclo[2.2.1]hept-5-ene-3-carboxylic acid ethyl ester 
• 135094-10-9 endo-2-aza-2-<(R)-1-phenylethyl>-3-ethoxycarbonyl<2.2.1>bicyclohept-5-ene 
• 135635-58-4 Ethyl (1R,3R,4S)-2-<(1R)-α-Phenylethyl>-2-azabicyclo<2.2.1>hept-5-ene-3-carboxylate 
• 134984-64-8 exo-2-aza-2-<(R)-1-phenylethyl>-3-ethoxycarbonyl<2.2.2>bicyclooct-5-ene 
• 205520-79-2 (1R,3R,4S)-2-((R)-1-Phenyl-ethyl)-2-aza-bicyclo[2.2.2]oct-5-ene-3-carboxylic acid ethyl ester 
• 135094-11-0 endo-2-aza-2-<(R)-1-phenylethyl>-3-ethoxycarbonyl<2.2.2>bicyclooct-5-ene 
• 139334-61-5 (6R)-1-<(R)-1-phenylethyl>-6-ethoxycarbonyl-3,4-dimethyl-3,4-didehydropiperidine 
• 139334-64-8 (6S)-1-<(R)-1-phenylethyl>-6-ethoxycarbonyl-3,4-dimethyl-3,4-didehydropiperidine hydrochloride 
• 134984-65-9 (6S)-1-<(R)-1-phenylethyl>-6-ethoxycarbonyl-3,4-dimethyl-3,4-didehydropiperidine 
• 134984-62-6 ethyl cis-(2S,4R)-1-<(R)-1-phenylethyl>-4-methylpipecolate 

Relevant articles and documents

RECEPTOR INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF

The present invention discloses a receptor inhibitor of formula (I), a pharmaceutical composition comprising the same and the use thereof.

ALKYNE COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS

Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R12 or R13 on the A group is alkyne substituent (R32) are provided. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein can reduce the excessive activation of complement.

Substituted piperidine amide derivative, preparation method thereof, and application of derivative to pharmacy

The invention relates to a substituted piperidine amide derivative as shown in a general formula (I) or a stereisomer and pharmaceutically acceptable salt thereof, a preparation method of the derivative, medicinal combination as well as application of the derivative to the aspects of local anaesthesia or analgesia. The definition of each group of the general formula (I) is consistent with that of the description. (The general formula (I) is as shown in the description).