37663-46-0

Basic information

• Product Name: Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one
• Synonyms: Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one;3H-Spiro[2-benzofuran-1,4'-piperidine]-3-one;3-Oxospiro[isobenzofuran-1(3H),4'-piperidine];Spiro[phthalan-1,4'-piperidin]-3-one;3H-spiro[isobenzofuran-1,4'-piperidin]-3-one
• CAS NO: 37663-46-0
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 203.24
• Mol File: 37663-46-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 132-133 °C
• Boiling Point: 406.849 °C at 760 mmHg
• Flash Point: 199.855 °C
• Appearance: /
• Density: 1.25
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.98±0.20(Predicted)
• CAS DataBase Reference: Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one(37663-46-0)
• EPA Substance Registry System: Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one(37663-46-0)

Safety Data

• Hazardous Substances Data: 37663-46-0(Hazardous Substances Data)

Usage

Uses

3H-Spiro[2-benzofuran-1,4''-piperidine]-3-one is used in the preparation of cyltransferase 1 Inhibitors.

Upstream product

• 37663-42-6 1'-benzylspiro[isobenzofuran-1(3H),4'-piperidine]-3-one 
• 93-98-1 N-phenyl benzoyl amide 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 54596-21-3 2-bromo-N-(2-hydroxy-1,1-dimethylethyl)benzamide 
• 54595-99-2 1-benzyl-4-[2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-phenyl]-piperidin-4-ol 
• 32664-13-4 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole 

Downstream Products

• 59043-42-4 1'-(2-hydroxy-2-phenyl-ethyl)-spiro[isobenzofuran-1,4'-piperidin]-3-one 
• 916344-81-5 C₂₁H₂₂ClNO₃ 
• 438190-93-3 1'-(trans-4-Ethoxycarbonyl-cyclohexylmethyl)carbamoyl-spiro [isobenzofuran-1,4'piperidin]3-one 
• 438190-64-8 (5-(3-methoxyphenyl)-1H-benzimidazol-2-yl)-spiro[isobenzofuran-1,4'-piperidin]-3-one 
• 438190-65-9 1'-(5-phenyl-1H-imidazo[4,5-b]pyrazin-2-yl)-spiro[isobenzofuran-1,4'-piperidin]-3-one 
• 56658-01-6 1'-(2-benzhydryloxy-ethyl)-spiro[isobenzofuran-1,4'-piperidin]-3-one 
• 915104-45-9 N-(4-Chlorophenyl)-3-oxo-1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1'-carbothioamide 
• 1034352-45-8 1'-(3,4-Dichlorobenzoyl)-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one 
• 328232-23-1 C₂₂H₂₀N₄O₃ 
• 1175705-86-8 C₂₂H₁₉N₃O₃S 
• 1175705-81-3 C₂₂H₂₀N₄O₃ 
• 1175705-74-4 C₂₃H₂₀N₄O₃ 
• 1101026-34-9 C₂₃H₂₀N₄O₃ 
• 1175705-88-0 C₂₁H₁₈N₄O₃S 

Relevant articles and documents

INDOL-3-YL-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES AS V1A RECEPTOR ANTAGONISTS

The invention relates to indol-3-yl-carbonyl-spiro-piperidine derivatives which act as V1a receptor antagonists and which are represented by Formula I: wherein the spiro-piperidine head group A and the residues R1, R2 and R3 are as defined herein. The invention further relates to pharmaceutical compositions containing such compounds, methods for preparing the compounds and pharmaceutical compositions, and their use in the treatment of dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxious and depressive disorders.

Spiro piperidines. I. Synthesis of spiro[isobenzofuran 1(3 H),4' piperidines] and spiro[isobenzofuran 1(3 H),3' piperidines]

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