37819-91-3Relevant articles and documents
Potential Anticancer Agents. XXVI. Spin Labelled Nitrosoureas
Baracu, Ileana,Dobre, V.,Niculescu-Duvaz, I.
, p. 667 - 674 (2007/10/02)
In order to obtain more information about the in vivo mechanism of action of nitrosoureas, the synthesis of spin labelled nitrosoureas derived from 1-oxyl-2.2.6.6-tetramethyl-4-aminopiperidine was undertaken.The synthesis of four spin labelled ureas 4a-4d was reported as well as two spin labelled nitrosoureas: 1-methyl-3-(2'.2'.6'.6'-tetramethyl-piperidin-4'-yl-1'-oxyl)-1-nitrosourea (9a) and 1-(2'-chloroethyl)-3-(2".2".6".6"-tetramethyl-piperidin-4"-yl-1"-oxyl)-1-nitrosourea (9b).Their e.s.r. spectra were recorded.None of these compounds proved to be active against L1210.