37858-07-4Relevant articles and documents
COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF INFECTIOUS DISEASES AND CANCER
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Page/Page column 35; 37; 39-40, (2021/02/26)
The invention provides the imidazole, oxazole and thiazole compounds and use thereof in methods for treating a disease or a disorder, such as infectious diseases and cancer, wherein inhibition of sphingosine-1-phosphate lyase is beneficial to treat the disease or the disorder.
Structure-property relationship study of n-(hydroxy)peptides for the design of self-assembled parallel β-sheets
Roche, Stéphane P.,Richaud, Alexis D.
, p. 12329 - 12342 (2020/11/10)
The design of novel and functional biomimetic foldamers remains a major challenge in creating mimics of native protein structures. Herein, we report the stabilization of a remarkably short β-sheet by incorporating N-(hydroxy)glycine (Hyg) residues into the backbone of peptides. These peptide- peptoid hybrids form unique parallel β-sheet structures by selfassembly upon hydrogenation. Our spectroscopic and crystallographic data suggest that the local conformational perturbations induced by N-(hydroxy)amides are outweighed by a network of strong interstrand hydrogen bonds.
In vitro and in silico evaluation of non-quaternary reactivators of AChE as antidotes of organophosphorus poisoning - A new hope or a blind alley?
Soukup, Ondrej,Korabecny, Jan,Malinak, David,Nepovimova, Eugenie,Pham, Ngoc L.,Musílek, Kamil,Hrabinova, Martina,Hepnarova, Vendula,Dolezal, Rafael,Pavek, Petr,Jost, Petr,Kobrlova, Tereza,Jankockova, Jana,Gorecki, Lukas,Psotka, Miroslav,Nguyen, Thuy D.,Box, Karl,Outhwaite, Breeze,Ceckova, Martina,Sorf, Ales,Jun, Daniel,Kuca, Kamil
, p. 281 - 292 (2018/05/17)
Background: In the last decade, the concept of uncharged reactivators potentially able to penetrate the CNS has been introduced as an alternative to the classic charged oxime reactivators. However, this concept brings with it several associated drawbacks
