3790-51-0

Basic information

• Product Name: H-ASP-GLY-OH
• Synonyms: L-ASPARTIC ACID-L-GLYCINE;H-ASP-GLY-OH;asp-gly;aspartylglycine;H-Asp-Glp-OH;L-aspartyl-glycine;L-Asp-Gly;N-(α-Aspartyl)glycine
• CAS NO: 3790-51-0
• Molecular Formula: C6H10N2O5
• Molecular Weight: 190.15
• Mol File: 3790-51-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 572 °C at 760 mmHg
• Flash Point: 299.7 °C
• Appearance: /
• Density: 1.499 g/cm³
• Vapor Pressure: 1.42E-14mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: -15°C
• CAS DataBase Reference: H-ASP-GLY-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-ASP-GLY-OH(3790-51-0)
• EPA Substance Registry System: H-ASP-GLY-OH(3790-51-0)

Safety Data

• Hazardous Substances Data: 3790-51-0(Hazardous Substances Data)

Usage

Definition

ChEBI: A dipeptide composed of L-aspartic acid and glycine joined by a peptide linkage.

InChI:InChI=1/C6H10N2O5/c7-3(1-4(9)10)6(13)8-2-5(11)12/h3H,1-2,7H2,(H,8,13)(H,9,10)(H,11,12)

Upstream product

• 40470-02-8 N-(O-benzyl-N-benzyloxycarbonyl-L-α-aspartyl)-glycine benzyl ester 
• 93566-85-9 N-Benzyl-α-L-aspartyl-glycin 
• 3338-32-7 Z-Asp(OtBu)-OSu 
• 56-40-6 glycine 
• 142757-75-3 isoasparaginylglycine 
• 55247-97-7 (S)-N-[Bis-(4-methoxy-phenyl)-methyl]-2-tert-butoxycarbonylamino-succinamic acid 
• 64817-62-5 t-butoxycarbonyl-L-asparagine anhydride 
• 39552-95-9 N-(N-benzyloxycarbonyl-L-α-aspartyl)-glycine ethyl ester 
• 503027-29-0 N-Benzyl-α-L-aspartyl-glycin-aethylester 

Relevant articles and documents

PEPTIDE COMPOUNDS AND METHODS OF USING PEPTIDE COMPOUNDS TO TREAT CONDITIONS AFFECTING THE CARDIAC, PULMONARY, AND NERVOUS SYSTEMS

The present invention provides a method of treating or preventing diseases or conditions affecting the cardiac, pulmonary and/or nervous systems in a subject using peptide compounds. The methods of the invention are useful for the treatment and prevention of a variety of disorders or conditions including, without limitation, ischemia, stroke, pulmonary diseases, allergic reactions, physical trauma to pulmonary tissues, exposure to harmful entities in the environment, and smoking.

A Quantitative Evaluation of Methods for Coupling Asparagine

A quantitative procedure was developed to evaluate methods for coupling asparagine.Boc-asparagine was coupled to glycyloxymethylphenoxymethyl-copoly(styrene-divinylbenzene) resin under a variety of conditions, and the product, Asn-Gly, and any byproducts were cleaved from the resin with 50percent trifluoroacetic acid in methylene chloride.The mixture was then separated on a sulfonated ion exchange column and quantitated by the ninhydrin reaction.Coupling by the dicyclohexylcarbodiimide (DCC) or symmetrical anhydride methods gave large amounts of the dehydration product, β-cyanoalanylglycine, and smaller amounts of β-aspartamidinoacetic acid, α-aspartylglycine, and β-aspartylglycine in addition to the desired asparaginylglycine.Activation of Boc-Asn by DCC plus hydroxybenzotriazole or by the nitrophenyl ester gave 98 to 99percent of Asn-Gly, but very low levels of the byproducts were detectable with the sensitive chromatographic method.Protection of the amide function of Boc-Asn with the 4,4'-dimethoxybenzhydryl group avoided completely the formation of the nitrile during DCC coupling.Pure Ala(CN)-Gly was quantitatively reconverted to Asn-Gly by HF.The rehydration of nitrile also occurred in 50percent trifluoroacetic acid in dichloromethane, but much more slowly.