37918-84-6Relevant articles and documents
Intermolecular Hydroamination of 1,3-Dienes to Generate Homoallylic Amines
Yang, Xiao-Hui,Lu, Alexander,Dong, Vy M.
, p. 14049 - 14052 (2017)
We report a Rh-catalyzed hydroamination of 1,3-dienes to generate homoallylic amines. Our work showcases the first case of anti-Markovnikov selectivity in the intermolecular coupling of amines and 1,3-dienes. By tuning the ligand properties and Br?nsted acid additive, we find that a combination of rac-BINAP and mandelic acid is critical for achieving anti-Markovnikov selectivity.