37949-03-4Relevant articles and documents
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Allinger,N.L.,Szkrybalo,W.
, p. 722 - 724 (1962)
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Uyehara,T. et al.
, p. 273 - 274 (1979)
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Two-carbon ring expansion of 1-indanones via insertion of ethylene into carbon-carbon bonds
Xia, Ying,Ochi, Shusuke,Dong, Guangbin
supporting information, p. 13038 - 13042 (2019/08/26)
A rhodium-catalyzed direct insertion of ethylene into a relatively unstrained carbon-carbon bond in 1-indanones is reported, which provides a two-carbon ring expansion strategy for preparing seven-membered cyclic ketones. As many 1-indanones are commercially available and ethylene is inexpensive, this strategy simplifies synthesis of benzocycloheptenones that are valuable synthetic intermediates for bioactive compounds but challenging to prepare otherwise. In addition, the reaction is byproduct-free, redox neutral, and tolerant of a wide range of functional groups, which may have implications on unconventional strategic bond disconnections for preparing complex cyclic molecules.
Bemcentinib: Rec INN
Gras
, p. 645 - 653 (2018/10/20)
Increased expression of Axl has been reported in various cancers including colon, esophageal, thyroid, breast, lung, liver and astrocytoma-glioblastoma. Cancer resistance to tyrosine kinase inhibitors and other chemotherapeutics has been correlated with a