380228-57-9

Basic information

• Product Name: 3',5'-DICHLORO-BIPHENYL-3-CARBOXYLIC ACID
• Synonyms: 3',5'-DICHLORO-BIPHENYL-3-CARBOXYLIC ACID;3-BIPHENYL-3',5'-DICHLORO-CARBOXYLIC ACID;3-(3,5-Dichlorophenyl)benzoic acid;3,5-Dichloro-[1,1-biphenyl]-3-carboxylic acid
• CAS NO: 380228-57-9
• Molecular Formula: C13H8Cl2O2
• Molecular Weight: 267.11
• Mol File: 380228-57-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 448°Cat760mmHg
• Flash Point: 224.7°C
• Appearance: /
• Density: 1.397g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3',5'-DICHLORO-BIPHENYL-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5'-DICHLORO-BIPHENYL-3-CARBOXYLIC ACID(380228-57-9)
• EPA Substance Registry System: 3',5'-DICHLORO-BIPHENYL-3-CARBOXYLIC ACID(380228-57-9)

Safety Data

• Hazardous Substances Data: 380228-57-9(Hazardous Substances Data)

Usage

General Description

3',5'-dichloro-biphenyl-3-carboxylic acid is a chemical compound that belongs to the class of biphenyl carboxylic acids. It is a derivative of biphenyl, a type of organic compound that contains two phenyl rings linked by a single bond. The presence of two chlorine atoms on the 3' and 5' positions of the biphenyl ring makes this compound a chlorinated biphenyl derivative. The carboxylic acid functional group on the 3-carbon of the biphenyl ring makes it a carboxylic acid derivative. 3',5'-DICHLORO-BIPHENYL-3-CARBOXYLIC ACID has potential applications in pharmaceutical and chemical industries, particularly in the synthesis of various organic compounds and pharmaceutical intermediates. However, it is important to handle and use this chemical with caution due to its potential toxicity and environmental impact.

Upstream product

• 656305-82-7 3',5'-dichloro-biphenyl-3-carbaldehyde 
• 3032-81-3 3,5-dichloroiodobenzene 
• 87199-16-4 3-Formylphenylboronic acid 
• 67492-50-6 (3,5-dichlorophenyl)boronic acid 
• 618-51-9 3-Iodobenzoic acid 

Relevant articles and documents

A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences

The nuclear retinoid X receptors (RXRs) are key ligand sensing transcription factors that serve as universal nuclear receptor heterodimer partners and are thus involved in numerous physiological processes. Therapeutic targeting of RXRs holds high potential but available RXR activators suffer from limited safety. Selectivity for RXR subtypes or for certain RXR heterodimers are promising strategies for safer RXR modulation. Here, we report systematic structure-activity relationship studies on biphenyl carboxylates as new RXR ligand chemotype. We discovered specific structural modifications that enhance potency on RXRs, govern subtype preference, and vary modulation of different RXR heterodimers. Fusion of these structural motifs enabled specific tuning of subtype preferential profiles with markedly improved potency. Our results provide further evidence that RXR subtype selective ligands can be designed and present a novel chemotype of RXR modulators that can be tuned for subtype and heterodimer preferences.