380304-54-1

Basic information

• Product Name: Thiourea, N-(2-fluorophenyl)-N'-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-
• CAS NO: 380304-54-1
• Molecular Formula: C11H15FN2O3S
• Molecular Weight: 274.316
• Mol File: 380304-54-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Thiourea, N-(2-fluorophenyl)-N'-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiourea, N-(2-fluorophenyl)-N'-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-(380304-54-1)
• EPA Substance Registry System: Thiourea, N-(2-fluorophenyl)-N'-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-(380304-54-1)

Safety Data

• Hazardous Substances Data: 380304-54-1(Hazardous Substances Data)

Upstream product

• 38985-64-7 o-fluorophenyl isothiocyanate 
• 77-86-1 2-amino-2-hydroxymethyl-1,3-propanediol 
• 348-54-9 2-Fluoroaniline 

Relevant articles and documents

Synthesis and quantitative structure - Activity relationships of fluorine-containing 4,4-dihydroxylmethyl-2-aryliminooxazo(thiazo)lidines as trehalase inhibitors

Five fluorine-containing 4,4-dihydroxylmethyl-2-aryliminooxazolidines and five 4,4-dihydroxylmethyl-2-aryliminothiazolidines were synthesized and evaluated for their inhibitory activity against trehalase in vitro. All these compounds were very readily synthesized compared with the natural trehalase inhibitors. They had moderate inhibitory activity toward trehalase, and showed larvicidal activity and inhibition action to insect flight. The steric parameters and semiempirical quantum parameters of these compounds were acquired by using the molecular modeling method and the PM3-SCF-MO method, respectively. A quantitative structure - activity relationship between half-inhibitory concentrations toward trehalase and the above parameters was established.