380482-31-5

Basic information

• Product Name: 3,4-DIETHOXYBENZHYDRAZIDE
• Synonyms: 3,4-DIETHOXYBENZHYDRAZIDE;3,4-DIETHOXYBENZOHYDRAZIDE;3,4-DIETHYOXYBENZHYDRAZIDE;AKOS B015354;ART-CHEM-BB B015354;FS000338;IVK/4031877;ZINC02574322
• CAS NO: 380482-31-5
• Molecular Formula: C11H16N2O3
• Molecular Weight: 224.26
• Mol File: 380482-31-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 164-166°C
• Appearance: /
• Density: 1.132 g/cm³
• Refractive Index: 1.532
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 3,4-DIETHOXYBENZHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIETHOXYBENZHYDRAZIDE(380482-31-5)
• EPA Substance Registry System: 3,4-DIETHOXYBENZHYDRAZIDE(380482-31-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36-22
• Safety Statements: 36-26
• HazardClass: IRRITANT
• Hazardous Substances Data: 380482-31-5(Hazardous Substances Data)

Usage

General Description

3,4-Diethoxybenzhydrazide, also known as DEBH, is a chemical compound used as a corrosion inhibitor in industrial applications. It is a white to cream-colored powder with a faint aromatic odor. DEBH is used to protect metal surfaces from corrosion in various industrial processes, such as oil and gas production, and in the manufacturing of products like fuels, solvents, and plastics. 3,4-DIETHOXYBENZHYDRAZIDE works by forming a protective film on metal surfaces, preventing the formation of rust and corrosion. DEBH is also used as an intermediate in the synthesis of other chemicals, such as dyes and pharmaceuticals. However, it is important to handle DEBH with care, as it is considered harmful if swallowed, and can cause irritation to the skin and eyes.

InChI:InChI=1/C11H16N2O3/c1-3-15-9-6-5-8(11(14)13-12)7-10(9)16-4-2/h5-7H,3-4,12H2,1-2H3,(H,13,14)

Upstream product

• 5409-31-4 3,4-diethoxybenzoic acid 
• 75332-44-4 3,4-diethoxybenzoic acid ethyl ester 

Relevant articles and documents

Rational modifications on a benzylidene-acrylohydrazide antiviral scaffold, synthesis and evaluation of bioactivity against Chikungunya virus

Chikungunya virus is a re-emerging arbovirus transmitted to humans by Aedes mosquitoes, responsible for an acute febrile illness associated with painful and debilitating arthralgia, which can persist for several months or become chronic. Over the past few years, infection with this virus has spread worldwide with a previously unknown virulence. No specific antiviral treatments nor vaccines are currently available against this important pathogen. Starting from the structure of a class of selective anti-CHIKV agents previously identified in our research group, different modifications to this scaffold were rationally designed, and 69 novel small-molecule derivatives were synthesised and evaluated for their inhibition of Chikungunya virus replication in Vero cells. Further structure-activity relationships associated with this class of antiviral agents were elucidated for the original scaffolds, and novel antiviral compounds with EC50 values in the low micromolar range were identified. This work provides the foundation for further investigation of these new structures as antivirals against Chikungunya virus.