38068-98-3Relevant articles and documents
Kinetics and Mechanism of Pyrrolidine Buffer-Catalyzed Fulvene Formation
Sieverding, Paul,Osterbrink, Johanna,Besson, Claire,K?gerler, Paul
, p. 486 - 494 (2019/01/11)
Rapid synthesis of fulvenes is achieved using pyrrolidinium/pyrrolidine buffers in anhydrous acetonitrile. Time-dependent UV-vis absorption and NMR spectroscopy reveal that the rate and yield of fulvene formation depend strongly on both the presence of acid in the medium and the choice of solvent, and they are negatively affected by water. Kinetic data have been collected for various substrates, and the synthetic benefits of the adjusted reaction conditions are showcased. Enhancements of reaction rates are found in comparison to literature procedures. α-Unsaturated fulvenes that were previously difficult to access can now be obtained in good yields.
Synthesis & antitumor activity of new group 3 Metallocene complexes
Caporale, Angelamaria,Palma, Giuseppe,Mariconda, Annaluisa,Del Vecchio, Vitale,Iacopetta, Domenico,Parisi, Ortensia Ilaria,Sinicropi, Maria Stefania,Puoci, Francesco,Arra, Claudio,Longo, Pasquale,Saturnino, Carmela
, (2017/04/10)
The quest for alternative drugs with respect to the well-known cis-platin and its derivatives, which are still used in more than 50% of the treatment regimens for patients suffering from cancer, is highly needed. In this context, organometallic compounds, which are defined as metal complexes containing at least one direct covalent metal-carbon bond, have recently been found to be promising anticancer drug candidates. A series of new metallocene complexes with scandium, yttrium, and neodymium have been prepared and characterized. Some of these compounds show a very interesting anti-proliferative activity in triple negative breast cancer cell line (MDA.MB231) and the non-hormone sensitive prostate cancer cell line (DU145). Moreover, the interaction of some of them with biological membranes, evaluated using liposomes as bio-membrane mimetic model systems, seems to be relevant. The biological activity of these compounds, particularly those based on yttrium, already effective at low concentrations on both cancer cell lines, should be taken into account with regard to new therapeutic approaches in anticancer therapy.
Asymmetric Pentafulvene Carbometalation - Access to Enantiopure Titanocene Dichlorides of Biological Relevance
Cini, Melchior,Bradshaw, Tracey D.,Woodward, Simon,Lewis, William
supporting information, p. 14179 - 14182 (2016/01/25)
Unprecedented asymmetric copper-catalyzed addition of ZnEt2 (ZnBu2) to the exocyclic C=C bond of pentafulvenes C5H4(=CHAr) (Ar=2-MeOPh and related species) results in enantiomerically enriched (up to 93:7 e.r.)
