3815-34-7Relevant articles and documents
Synthetic method of methyl ketone compound
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Paragraph 0072-0079, (2020/06/16)
The invention relates to the technical field of organic synthesis, and provides a synthesis method for a methyl ketone compound. The synthesis method comprises the following steps: mixing terminal alkyne, an organic solvent, an acid and water, and carrying out a hydration reaction to obtain a methyl ketone compound. According to the synthetic method provided by the invention, the use a catalyst containing metal ions and an oxidizing agent can be avoided, the raw materials are directly subjected to the hydration reaction in the presence of acid and water, and the complicated operation of removing metal ions is avoided in the post-treatment process of the produced methyl ketone compound; the method provided by the invention is high in raw material conversion rate and relatively high in product yield and product purity; the synthesis reaction process is simple and convenient to operate, green and environment-friendly, and suitable for large-scale industrial production; the synthetic method provided by the invention is mild in reaction conditions and easy to control. Results of an embodiment of the invention show that when the method is used for preparing the methyl ketone compound, yield can reach 96.4%, and product purity reaches 99.2%.
Diastereo- and regioselective synthesis of diquinanes and related systems from tricyclo[3.3.0.02,4]octanes by chemical electron transfer (CET)
Adam,Heidenfelder,Sahin
, p. 1163 - 1170 (2007/10/02)
A new synthetic methodology for diquinanes by one-electron oxidation of tricyclo[3.3.0.02,4]octanes and subsequent stereocontrolled rearrangement is provided. The latter compounds are conveniently accessible through acid-catalyzed isopyrazole cycloaddition, followed by hydrogenation and photoextrusion of molecular nitrogen. The oxidative rearrangement of the tricyclooctanes proceeds catalytically and cleanly to afford regio- and diastereoselectively the corresponding diquinanes.
Selective α-Mono- and α,α-Dialkylations of 1,3-Diketones Using Solid Base Prepared from Sodium Ethoxide and Alumina
Yoshihara, Nobutoshi,Kitagawa, Teruhiro,Ihara, Ikuko,Hasegawa, Sadao,Hasegawa, Tadashi
, p. 1185 - 1187 (2007/10/02)
The alkylation of 1,3-diketones with alkyl halides using a solid base prepared from sodium ethoxide and alumina was carried out.The amount of 0.4 mol of sodium ethoxide on 50 g of alumina showed by best reactivity for alkylation.Selective mono- and dialky