38199-30-3Relevant articles and documents
THERMAL REARRANGEMETS OF SOME INDOLE ALKALOID DERIVATIVES
Hugel, Georgette,Levy, Jean
, p. 1067 - 1074 (2007/10/02)
Under both static and flow thermolysis conditions, several compounds with an "aspidosperma" framework rearranged to "vinca" derivatives.Thus (-)1,2-dehydroaspidospermidine (4) rearranged to (-)aspidospermidine and compound 17 on pyrolysis (200 deg C) while flow termolysis (580 deg C) gave vincane (14).Compound 6 rearranged to vincamine (13a) and 16-epivincamine (13b) under either condition; increasing the temperature resulted in formation of apovincamine (19) (pyrolysis) or vincamone (16) (flow thermolysis).