38240-76-5

Basic information

• Product Name: 1-benzoyl-4-(4-tolyl)thiosemicarbazide
• Synonyms: 1-benzoyl-4-(4-tolyl)thiosemicarbazide
• CAS NO: 38240-76-5
• Molecular Formula: C₁₅H₁₅N₃OS
• Molecular Weight: 0
• Mol File: 38240-76-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.275g/cm³
• Refractive Index: 1.682
• CAS DataBase Reference: 1-benzoyl-4-(4-tolyl)thiosemicarbazide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzoyl-4-(4-tolyl)thiosemicarbazide(38240-76-5)
• EPA Substance Registry System: 1-benzoyl-4-(4-tolyl)thiosemicarbazide(38240-76-5)

Safety Data

• Hazardous Substances Data: 38240-76-5(Hazardous Substances Data)

Usage

Chemical class

Thiosemicarbazides

Appearance

White to off-white crystalline powder

Solubility

Sparingly soluble in water

Melting point

Around 180-183°C

Pharmacological activities

Anti-cancer, anti-inflammatory, and antimicrobial properties

Efficacy

Inhibits the growth of cancer cells, reduces inflammation, and demonstrates antimicrobial activity against a range of bacteria and fungi

Potential

Further research and development in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C15H15N3OS/c1-11-7-9-13(10-8-11)16-15(20)18-17-14(19)12-5-3-2-4-6-12/h2-10H,1H3,(H,17,19)(H2,16,18,20)

Upstream product

• 613-94-5 benzoic acid hydrazide 
• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 96989-50-3 di-2-pyridyl thionocarbonate 
• 106-49-0 p-toluidine 
• 93-99-2 benzoic acid phenyl ester 
• 5285-74-5 4-tolyl thiocyanate 

Downstream Products

• 63314-58-9 4-(4-methylphenyl)-5-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione 
• 63314-61-4 N-(4-methylphenyl)-5-phenyl-1,3,4-thiadiazol-2-amine 
• 109940-94-5 N-(phenyl-[1,3,4]thiadiazol-2-yl)-N-p-tolyl-acetamide 
• 1617-95-4 5-phenyl-N-(p-tolyl)-1,3,4-oxadiazol-2-amine 

Relevant articles and documents

A KHSO4 mediated facile synthesis of 2-amino-1,3,4-oxadiazole derivatives

A novel, efficient and mild KHSO4 mediated synthesis for 2-amino-1,3,4-oxadiazoles has been established via the cyclodesulfurization of benzoylhydrazine and isothiocyanate derivatives in one pot. The reactions proceeded smoothly at room tempera

Antimicrobial and Physicochemical Characterizations of Thiosemicarbazide and S-Triazole Derivatives

Two series of thiosemicarbazide derivatives and three series of s-triazole derivatives have been synthesized. All of these compounds were tested for their in vitro antibacterial activity against Gram-positive and Gram-negative bacterial strains. Among tested thiosemicarbazide derivatives, the best bioactivity was detected for two 1-formylthiosemicarbazides with 3-/4-tolyl substitution (1 l, 1 m) (MICs range between 31.25 and 250 μg/mL). All tested s-triazole derivatives exhibited lower antibacterial activity than their acyclic precursors.

Desulfurization strategy in the construction of azoles possessing additional nitrogen, oxygen or sulfur using a copper(I) catalyst

A tandem and convergent approach to various N-, O-, or S-containing azoles has been developed by exploiting the thiophilic property of copper( I) iodide used in a catalytic quantity. The present protocol gives access to amino-substituted tetrazoles, triazoles, oxadiazoles and thiadiazoles via oxidative desulfurization of their respective precursors followed by inter- or intramolecular attack of suitable nucleophiles. For aminotetrazoles and triazoles an excellent regioselectivity has been achieved through proper tuning of the pKa values of the parent amines attached to unsymmetrical thioureas. The method represents an autocatalytic process in which copper( I) iodide gets converted to copper(II) sulfide which in turn transforms to active copper(II) oxide that effectively carries forward the catalytic cycle. The fate of the copper catalyst has also been studied using scanning electron microscopic (SEM) and energy-dispersive X-ray spectroscopic (EDS) analyses which give an insight into the mechanism for this catalytic process.