3831-29-6

Basic information

• Product Name: 4-fluorobenzyl iodide
• Synonyms: 4-fluorobenzyl iodide;1-Fluoro-4-iodomethyl-benzene
• CAS NO: 3831-29-6
• Molecular Formula: C₇H₆FI
• Molecular Weight: 236.03
• Mol File: 3831-29-6.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 222.4°C at 760 mmHg
• Flash Point: 91.7°C
• Appearance: /
• Density: 1.832g/cm³
• Vapor Pressure: 0.151mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: 4-fluorobenzyl iodide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-fluorobenzyl iodide(3831-29-6)
• EPA Substance Registry System: 4-fluorobenzyl iodide(3831-29-6)

Safety Data

• Hazardous Substances Data: 3831-29-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H6FI/c8-7-3-1-6(5-9)2-4-7/h1-4H,5H2

Upstream product

• 459-46-1 4-Fluorobenzyl bromide 
• 1003-09-4 2-bromothiophene 
• 459-57-4 4-fluorobenzaldehyde 
• 459-56-3 4-fluorobenzylic alcohol 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 352-32-9 p-fluorotoluene 

Downstream Products

• 2408-06-2 (4-fluorobenzyl)(trifluoromethyl)sulfane 
• 99793-18-7 1,5-Bis-(4-chloro-phenyl)-3-(4-fluoro-benzylsulfanyl)-1H-[1,2,4]triazole 
• 136794-76-8 4'-O-demethyl-4β-[(4''-fluorobenzyl)amino]-4-desoxypodophyllotoxin 
• 63877-96-3 2-(4-fluorophenylmethyl)thiophene 
• 587-79-1 4-fluorodiphenylmethane 
• 2408-05-1 1-fluoro-4-(((trifluoromethyl)sulfinyl)methyl)benzene 
• 2408-04-0 1-fluoro-4-((trifluoromethylsulfonyl)methyl)benzene 
• 57265-36-8 1-[2,4-Dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]-3-(p-fluorobenzyl)-imidazolium iodide 
• 101023-55-6 imidazole hydrobromide 
• 824-75-9 p-fluorobenzamide 
• 897767-45-2 methyl N-(4-fluoro)benzyl-4H-thieno[3,2-b]pyrrole carboxylate 

Relevant articles and documents

One-Pot Deoxygenation and Substitution of Alcohols Mediated by Sulfuryl Fluoride

Sulfuryl fluoride is a valuable reagent for the one-pot activation and derivatization of aliphatic alcohols, but the highly reactive alkyl fluorosulfate intermediates limit both the types of reactions that can be accessed as well as the scope. Herein, we report the SO2F2-mediated alcohol substitution and deoxygenation method that relies on the conversion of fluorosulfates to alkyl halide intermediates. This strategy allows the expansion of SO2F2-mediated one-pot processes to include radical reactions, where the alkyl halides can also be exploited in the one-pot deoxygenation of primary alcohols under mild conditions (52-95% yield). This strategy can also enhance the scope of substitutions to nucleophiles that are previously incompatible with one-pot SO2F2-mediated alcohol activation and enables substitution of primary and secondary alcohols in 54-95% yield. Chiral secondary alcohols undergo a highly stereospecific (90-98% ee) double nucleophilic displacement with an overall retention of configuration.

Preparation method of benzyl iodide and derivatives thereof

The invention discloses a preparation method of benzyl iodide and derivatives thereof, which comprises the following steps: in a protective atmosphere, carrying out heating reaction on aryl aldehyde and iodine elementary substance in the presence of a solvent and phosphorous acid to obtain benzyl iodide and derivatives thereof. According to the method, cheap and green solid phosphorous acid is selected as a reduction reagent for reaction, elemental iodine is selected as an iodine source, the benzyl iodide and the derivatives thereof are efficiently prepared from the aryl aldehyde compounds which are simple and easy to obtain by a one-pot one-step method under mild conditions, and the method has the advantages of simplicity in operation, cheap and easily available reagents, environmental friendliness and the like; and the use of expensive silicon-hydrogen compounds and transition metal catalysts is avoided, and the yield can reach 94% at most, so that the method is beneficial to industrial production.

Rhodium-Catalyzed Generation of Anhydrous Hydrogen Iodide: An Effective Method for the Preparation of Iodoalkanes

The preparation of anhydrous hydrogen iodide directly from molecular hydrogen and iodine using a rhodium catalyst is reported for the first time. The anhydrous hydrogen iodide generated was proven to be highly active in the transformations of alkenes, phenyl aldehydes, alcohols, and cyclic ethers to the corresponding iodoalkanes. Therefore, the present methodology not only has provided convenient access to anhydrous hydrogen iodide but also offers a practical preparation method for various iodoalkanes in excellent atom economy.