383133-83-3

Basic information

• Product Name: 4-(2,4-diethoxy-phenyl)-2-aminothiazole
• Synonyms: 4-(2,4-diethoxy-phenyl)-2-aminothiazole
• CAS NO: 383133-83-3
• Molecular Weight: 264.348
• Mol File: 383133-83-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2,4-diethoxy-phenyl)-2-aminothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,4-diethoxy-phenyl)-2-aminothiazole(383133-83-3)
• EPA Substance Registry System: 4-(2,4-diethoxy-phenyl)-2-aminothiazole(383133-83-3)

Safety Data

• Hazardous Substances Data: 383133-83-3(Hazardous Substances Data)

Upstream product

• 22924-18-1 2′,4′-diethoxyacetophenone 
• 17356-08-0 thiourea 

Downstream Products

• 1107621-07-7 (E)-N-((1H-indol-3-yl)methylene)-4-(2,4-diethoxyphenyl)thiazol-2-amine 

Relevant articles and documents

Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-Ribose) polymerase-1 inhibitors

A series of novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors were designed within 2-aminothiazole analogues (4-10) based on a constructed three-dimensional pharmacophore model. After synthesis, the inhibitory effect on PARP-1 activity and the cytoprotective action of these compounds were tested and evaluated. Among them, compounds 4-6 and 10 appeared to be potent PARP-1 inhibitors with IC50 values less than 1 μM, which had been perfectly predicted by pharmacophore model. These compounds proved to be highly potent against cell injury induced by H2O2 and oxygen-glucose deprivation (OGD) in PC12 cells. These novel 2-aminothiazole analogues are potentially applicable as neuroprotective agents for the treatment of neurological diseases.