384-98-5 Usage
Description
2,4,6-TRIMETHYLBENZENESULFONYL FLUORIDE is an organic compound that features a sulfonyl fluoride motif. This motif allows it to act as a connector for the assembly of -SO2linked small molecules with proteins or nucleic acids. It is a part of a new click chemistry approach through sulfates, which complements the use of amides and phosphate groups as linkers.
Uses
Used in Chemical Synthesis:
2,4,6-TRIMETHYLBENZENESULFONYL FLUORIDE is used as a connector in chemical synthesis for the assembly of -SO2linked small molecules with proteins or nucleic acids. Its sulfonyl fluoride motif enables the formation of stable and functional linkages, which can be useful in various chemical reactions and the development of new compounds.
Used in Click Chemistry:
2,4,6-TRIMETHYLBENZENESULFONYL FLUORIDE is used as a component in click chemistry approaches through sulfates. This method provides an alternative to using amides and phosphate groups as linkers, offering new possibilities for the creation of complex molecular structures and the development of innovative materials and drugs.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,4,6-TRIMETHYLBENZENESULFONYL FLUORIDE can be used as a building block for the development of new drugs. Its ability to form -SO2linked small molecules with proteins or nucleic acids can contribute to the design of novel therapeutic agents with improved efficacy and selectivity.
Used in Bioconjugation:
2,4,6-TRIMETHYLBENZENESULFONYL FLUORIDE is used as a bioconjugation agent for the attachment of small molecules to proteins or nucleic acids. This can be useful in the development of targeted drug delivery systems, biosensors, and other bioanalytical tools.
Overall, 2,4,6-TRIMETHYLBENZENESULFONYL FLUORIDE is a versatile compound with potential applications in various fields, including chemical synthesis, click chemistry, pharmaceuticals, and bioconjugation. Its unique sulfonyl fluoride motif allows for the formation of stable and functional linkages, making it a valuable component in the development of new materials and therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 384-98-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,8 and 4 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 384-98:
(5*3)+(4*8)+(3*4)+(2*9)+(1*8)=85
85 % 10 = 5
So 384-98-5 is a valid CAS Registry Number.
384-98-5Relevant articles and documents
Copper-catalyzed three-component reaction of arylhydrazine hydrochloride, DABSO, and NFSI for the synthesis of arenesulfonyl fluorides
Chen, Qing-Yun,Guo, Yong,Hu, Xiaojun,Liu, Chao,Liu, Yongan,Ma, Xiaoyu,Pan, Qijun,Pang, Wan,Wu, Jingjing
supporting information, p. 8999 - 9003 (2021/11/04)
This paper reports a convenient copper-catalyzed three-component conversion of arylhydrazine hydrochlorides to arenesulfonyl fluorides in good yields under mild conditions, using 1,4-diazabicyclo [2.2.2]octane bis(sulfur dioxide) (DABSO) as a sulfonyl source andN-fluorobenzenesulfonimide (NFSI) as a fluorine source based on a radical sulfur dioxide insertion and fluorination strategy. Notably, arylhydrazine hydrochloride is used as a safe precursor of aryl radicals.
Metal-Free Visible-Light Synthesis of Arylsulfonyl Fluorides: Scope and Mechanism
Louvel, Dan,Chelagha, Aida,Rouillon, Jean,Payard, Pierre-Adrien,Khrouz, Lhoussain,Monnereau, Cyrille,Tlili, Anis
supporting information, p. 8704 - 8708 (2021/05/17)
The first metal-free procedure for the synthesis of arylsulfonyl fluorides is reported. Under organo-photoredox conditions, aryl diazonium salts react with a readily available SO2 source (DABSO) to afford the desired product through simple nucleophilic fluorination. The reaction tolerates the presence of both electron-rich and -poor aryls and demonstrated a broad functional group tolerance. To shed the light on the reaction mechanism, several experimental techniques were combined, including fluorescence, NMR, and EPR spectroscopy as well as DFT calculations.
Facile one-pot synthesis of sulfonyl fluorides from sulfonates or sulfonic acids
Jiang, Ying,Alharbi, Njud S.,Sun, Bing,Qin, Hua-Li
, p. 13863 - 13867 (2019/05/17)
A facile cascade process for directly transforming the abundant and inexpensive sulfonates (or sulfonic acids) to the highly valuable sulfonyl fluorides was developed. This new protocol features mild reaction conditions using readily available and easy-to-operate reagents. A diverse set of sulfonyl fluorides was prepared facilitating the enrichment of the sulfonyl fluoride library.
