38401-70-6

Basic information

• Product Name: 5-(4-BROMOPHENYL)THIOPHENE-2-CARBALDEHYDE
• Synonyms: 5-(4-bromophenyl)-2-Thiophenecarboxaldehyde
• CAS NO: 38401-70-6
• Molecular Formula: C₁₁H₇BrOS
• Molecular Weight: 267.15
• Mol File: 38401-70-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-(4-BROMOPHENYL)THIOPHENE-2-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-BROMOPHENYL)THIOPHENE-2-CARBALDEHYDE(38401-70-6)
• EPA Substance Registry System: 5-(4-BROMOPHENYL)THIOPHENE-2-CARBALDEHYDE(38401-70-6)

Safety Data

• Hazardous Substances Data: 38401-70-6(Hazardous Substances Data)

Usage

General Description

5-(4-Bromophenyl)thiophene-2-carbaldehyde is a chemical compound with the molecular formula C12H8Br2OS. It is a yellow to brown solid with a molecular weight of 328.08 g/mol. 5-(4-BROMOPHENYL)THIOPHENE-2-CARBALDEHYDE is commonly used as a building block in the synthesis of various organic compounds, particularly in the field of pharmaceuticals and materials science. It contains a thiophene ring substituted with a bromophenyl group and an aldehyde functional group at the 2-position. 5-(4-Bromophenyl)thiophene-2-carbaldehyde has the potential to exhibit a variety of chemical reactivities, making it an important intermediate in organic synthesis.

Upstream product

• 40133-22-0 2-(4-bromophenyl)thiophene 
• 68-12-2 N,N-dimethyl-formamide 
• 108-86-1 bromobenzene 
• 4559-96-0 1-(4-bromophenyl)-4-chlorobutan-1-one 
• 589-87-7 1,4-bromoiodobenzene 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 5467-74-3 4-Bromophenylboronic acid 

Downstream Products

• 108967-84-6 2-(4-{(E)-2-[5-(4-Bromo-phenyl)-thiophen-2-yl]-vinyl}-phenyl)-5-phenyl-oxazole 
• 344417-31-8 2-Hydroxymethyl-5-(p-bromophenyl)thiophene 
• 108967-91-5 2-(4-{(E)-2-[5-(4-Bromo-phenyl)-thiophen-2-yl]-vinyl}-phenyl)-5-phenyl-[1,3,4]oxadiazole 
• 40133-13-9 5-(4-bromo-phenyl)-thiophene-2-carboxylic acid 
• 1195960-98-5 2-(4-((5-(4-bromophenyl)thiophen-2-yl)methylene)-5-oxo-2-thioxoimidazolidin-1-yl)-3-phenylpropanoic acid 
• 1236000-70-6 {[5-(4-bromophenyl)-2-thienyl]methyl}methyl({4[(trifluoromethyl)oxy]phenyl}methyl)amine 
• 1313397-37-3 5-((5-(4-bromophenyl)thiophen-2-yl)methylene)-2-thioxoimidazolidin-4-one 
• 85093-02-3 2-(p-bromophenyl)-5-methylthiophene 

Relevant articles and documents

Design, synthesis and evaluation of phenylthiazole and phenylthiophene pyrimidindiamine derivatives targeting the bacterial membrane

As the continuous rise in the incidence of antibiotic resistance, it is urgent to develop novel chemical scaffolds with antibacterial activities to control the spread of resistance to conventional antibiotics. In this study, a series of phenylthiazole and

Cyclic thiourea functionalized dyes with binary π-linkers: Influence of different π-conjugation segments on the performance of dye-sensitized solar cells

A series of cyclic thiourea functionalized dyes containing binary π-linkers were synthesized and applied in the dye-sensitized solar cells. The only difference of these dyes is that one segment of the binary π-linkers is thiophene, n-hexylthiophene, thienothiophene, 3,4-ethylenedioxythiophene, and benzene, respectively. Among them, the dyes incorporating electron-rich thienothiophene or 3,4-ethylenedioxythiophene exhibit the broader absorption bands and higher molar extinction coefficients in the visible region, which can not only enhance the light-harvesting ability but also improve the short-circuit current density; on the other hand, the dyes bearing bulky n-hexylthiophene or 3,4-ethylenedioxythiophene can effectively suppress the intermolecular π-π aggregation and electron recombination owing to larger steric hindrance, which is beneficial to increase the open-circuit voltage.

Development of dual functional SPECT/fluorescent probes for imaging cerebral β-amyloid plaques

The imaging of β-amyloid (Aβ) aggregates in the brain may lead to the early detection of Alzheimer's disease (AD) and monitoring of the progression and effectiveness of treatment. The purpose of this study was to develop dual modality SPECT and fluorescent probes based on boron dipyrromethane (BODIPY) as a core structure. We designed and synthesized an 125I-labeled derivative of BODIPY (BODIPY7). BODIPY7 had a K i value of 108 nM for Aβ(1-42) aggregates and exhibited peaks of absorption/emission at 606/613 nm. It detected Aβ plaques in sections of brain tissue from an animal model of AD and displayed low uptake in the brain and high uptake in the liver in normal mice. Although additional modifications of the BODIPY scaffold are necessary to improve brain uptake, these results should aid the development of dual functional SPECT/fluorescent probes for the imaging of Aβ plaques in the brain.