38448-95-2

Basic information

• Product Name: 1,3-Propanedione, 1-(4-fluorophenyl)-3-phenyl-
• CAS NO: 38448-95-2
• Molecular Formula: C15H11FO2
• Molecular Weight: 242.25
• Mol File: 38448-95-2.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 1,3-Propanedione, 1-(4-fluorophenyl)-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Propanedione, 1-(4-fluorophenyl)-3-phenyl-(38448-95-2)
• EPA Substance Registry System: 1,3-Propanedione, 1-(4-fluorophenyl)-3-phenyl-(38448-95-2)

Safety Data

• Hazardous Substances Data: 38448-95-2(Hazardous Substances Data)

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 98-88-4 benzoyl chloride 
• 39833-45-9 3-(4-fluorophenyl)-1-phenylprop-2-yn-1-one 
• 82677-84-7 1-(4-fluorophenyl)-3-phenylprop-2-yn-1-one 
• 932-90-1 Benzaldoxime 
• 70-11-1 α-bromoacetophenone 
• 156276-23-2 methyl (p-fluorobenzoyl)formate 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 93-58-3 benzoic acid methyl ester 
• 403-33-8 methyl 4-flurobenzoate 
• 98-86-2 acetophenone 
• 93-99-2 benzoic acid phenyl ester 
• 93-89-0 benzoic acid ethyl ester 

Downstream Products

• 4640-67-9 3-(4-fluorophenyl)-3-oxopropionitrile 
• 1599477-70-9 2,4-dibenzoyl-1,5-bis(4-fluorophenyl)pentane-1,5-dione 
• 94-41-7 benzalacetophenone 
• 3834-66-0 (4-fluorophenyl)phenylethanedione 
• 64027-78-7 (p-fluorobenzoyl)(thiobenzoyl)methane 

Relevant articles and documents

Method for synthesizing 1, 3-dicarbonyl compound based on terminal alkyne and acyl halide by one-pot process

The invention belongs to the technical field of catalytic synthesis, and discloses a method for synthesizing a 1, 3-dicarbonyl compound by a one-pot process, and the method comprises the following steps: by using simple palladium and copper salts as catalysts, reacting terminal alkyne with acyl halide at 0-80 DEG C for 0.5-12 hours under the action of trifluoromethanesulfonic acid to obtain the 1,3-dicarbonyl compound, wherein the molar ratio of the terminal alkyne to the acyl halide to the palladium salt to the copper salt to the trifluoromethanesulfonic acid is 1 to (1 to 2) to (0.00001 to0.10) to (0.00001 to 0.10) to (0.00004 to 0.40); the catalysts used in the method are common the commercialized palladium salt and copper salt, reagents used in the reaction are commercialized reagents, in addition, the raw materials are cheap and easy to obtain, functional group tolerance is good, reaction conditions are mild, operation is easy and convenient, and atom economy is high.

Novel Bifunctionalization of Activated Methylene: Base-Promoted Trifluoromethylthiolation of β-Diketones with Trifluoromethanesulfinyl Chloride

A novel bifunctionalization of activated methylene was achieved successfully through the base-promoted trifluoromethylthiolation of β-diketones or β-ketoesters with trifluoromethanesulfinyl chloride. A series of α-trifluoromethylthiolated α-chloro-β-diketones and α-chloro-β-ketoesters were obtained in moderate to good yields under mild conditions. When β-diketones containing a phenyl group with a hydroxyl or amino substituent at the ortho position were used as substrates, intramolecular trifluoromethylthiolation/cyclization reaction took place to give the corresponding cyclic products. Furthermore, the protocol could be extended to perfluoroalkylthiolation with the sodium perfluoroalkanesulfinate/POCl3 system. On the basis of experimental results, plausible mechanisms are proposed.

An effective preparation of both 1,3-diketones and nitriles from alkynones with oximes as hydroxide sources

An effective phosphine-catalyzed protocol has been established for the syntheses of 1,3-diketones and nitriles from alkynones with oximes as hydroxide surrogates. This method features the use of a phosphine catalyst, compatibility with various functional groups and ambient temperature, which makes this approach very practical. A plausible mechanism was proposed.