38489-70-2 Usage
Description
(E)-3-(benzo[d][1,3]dioxol-4-yl)acrylic acid is a chemical compound characterized by its molecular formula C10H8O4. It is a derivative of acrylic acid, featuring a benzo[d][1,3]dioxole ring structure. (E)-3-(benzo[d][1,3]dioxol-4-yl)acrylic acid is known for its potential applications in the pharmaceutical and agrochemical industries, as well as its possible use in the synthesis of various organic compounds. Its biological activity also makes it a subject of interest for further research in medicinal chemistry and drug development. Moreover, (E)-3-(benzo[d][1,3]dioxol-4-yl)acrylic acid may find industrial applications in the production of polymers or other materials.
Uses
Used in Pharmaceutical Industry:
(E)-3-(benzo[d][1,3]dioxol-4-yl)acrylic acid is used as a building block for the synthesis of pharmaceutical compounds due to its unique chemical structure and potential biological activity. Its incorporation into drug molecules can lead to the development of new therapeutic agents with improved efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical industry, (E)-3-(benzo[d][1,3]dioxol-4-yl)acrylic acid is utilized as a key intermediate in the development of novel agrochemicals, such as pesticides and herbicides. Its chemical properties allow for the creation of compounds with enhanced performance and selectivity, contributing to more effective and environmentally friendly agricultural practices.
Used in Organic Synthesis:
(E)-3-(benzo[d][1,3]dioxol-4-yl)acrylic acid is used as a versatile intermediate in organic synthesis, enabling the creation of a wide range of organic compounds with diverse applications. Its unique structure and reactivity make it a valuable component in the synthesis of complex molecules for various industries, including pharmaceuticals, materials science, and specialty chemicals.
Used in Polymer Production:
(E)-3-(benzo[d][1,3]dioxol-4-yl)acrylic acid may be employed as a monomer in the production of polymers or other materials, potentially leading to the development of new materials with improved properties. Its incorporation into polymer chains can result in materials with enhanced mechanical, thermal, or chemical resistance, among other benefits.
Used in Medicinal Chemistry Research:
(E)-3-(benzo[d][1,3]dioxol-4-yl)acrylic acid is used as a subject of interest in medicinal chemistry research due to its potential biological activity. Scientists are exploring its interactions with biological targets and its potential to be developed into new therapeutic agents for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 38489-70-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,4,8 and 9 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 38489-70:
(7*3)+(6*8)+(5*4)+(4*8)+(3*9)+(2*7)+(1*0)=162
162 % 10 = 2
So 38489-70-2 is a valid CAS Registry Number.
38489-70-2Relevant articles and documents
PYRIDINONE ANTAGONISTS OF ALPHA-4 INTEGRINS
-
Page/Page column 89-90, (2010/11/17)
The present invention provides compounds that are alpha4 integrin antagonists having a structure according to the following formula (I) or a tautomer, mixture of tautomers, salt or solvate thereof, wherein Cy, ring A, m, n, p, R1, R2
Nonneurotoxic Tetralin and Indian Analogues of 3,4-(Methylenedioxy)amphetamine (MDA)
Nichols, David E.,Brewster, William K.,Johnson, Michael P.,Oberlender, Robert,Riggs, Robert M.
, p. 703 - 710 (2007/10/02)
Four cyclic analgues of the psychoactive phenethylamine derivative 3,4-(methylenedioxy)amphetamine were studied.These congeners, 5,6- and 4,5-(methylenedioxy)-2-aminoindan (3a and 4a, respectively), and 6,7- and 5,6-(methylenedioxy)-2-aminotetralin (3b and 4b, respectively) were tested for stimulus generalization in the two-lever drug-discrimination paradigm.Two groups of rats were trained to discriminate either LSD tartrate (0.08 mg/kg) from saline, or (+/-)-MDMA*HCl (1.75 mg/kg) from saline.In addition, a 2-aminoindan (5a) and 2-aminotetralin (5b) congener of the hallucinogenic amphetamine 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) were also evaluated.None of the methylenedioxy compounds substituted in LSD-trained rats, while both 3a and 3b fully substituted in MDMA-trained rats.Compounds 4a and 4b did not substitute in MDMA-trained rats.Compounds 5a and 5b did not substitute in MDMA-trained rats, although 5a substituted in LSD-trained rats, but with relatively low potency compared to its open-chain counterpart.In view of the now well-established serotonin neurotoxicity of 3,4-(methylenedioxy)amphetamine and its N-methyl homologue 1, 3a and 3b were evaluated and compared to 1 for similar toxic effects following a single acute dose of 40 mg/kg sc.Sacrifice at 1 week showed that neither 3a nor 3b depressed rat cortical or hippocampal 5-HT or 5-HIAA levels nor were the number of binding sites (Bmax) depressed for paroxetine.By contrast, and in agreement with other reports, 1 significantly depressed all three indices of neurotoxicity.These results indicate that 3a and 3b have acute behavioral pharmacology similar to 1 but that they lack similar serotonin neurotoxicity.
