38512-35-5

Basic information

• Product Name: 1-(1-diazo-2,2,2-trifluoroethyl)-4-methylbenzene
• Synonyms: 1-(1-diazo-2,2,2-trifluoroethyl)-4-methylbenzene
• CAS NO: 38512-35-5
• Molecular Weight: 200.163
• Mol File: 38512-35-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(1-diazo-2,2,2-trifluoroethyl)-4-methylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-diazo-2,2,2-trifluoroethyl)-4-methylbenzene(38512-35-5)
• EPA Substance Registry System: 1-(1-diazo-2,2,2-trifluoroethyl)-4-methylbenzene(38512-35-5)

Safety Data

• Hazardous Substances Data: 38512-35-5(Hazardous Substances Data)

Upstream product

• 394-59-2 2,2,2-trifluoro-1-(p-tolyl)ethanone 

Downstream Products

• 136603-58-2 3-oxa-6,7-diaza-8-trifluoromethyl-8-(p-tolyl)-bicyclo<3.3.0>oct-6-ene-2,4-dione 
• 136603-51-5 3-carbethoxy-3,5-bis(trifluoromethyl)-5-p-tolyl-1-pyrazoline 
• 136603-53-7 1,2-bis(trifluoromethyl)-p,p'-dimethylstilbene 
• 136603-57-1 trifluoromethyl p-tolyl ketone azine 
• 136603-52-6 3,4-dicarbomethoxy-5-trifluoromethyl-5-p-tolyl-2-pyrazoline 
• 136603-50-4 3-cyano-5-trifluoromethyl-5-(p-tolyl)-2-pyrazoline 
• 136603-48-0 3-carbomethoxy-3-methyl-5-trifluoromethyl-5-(p-tolyl)-1-pyrazoline 
• 136603-56-0 5-phenyl-3-(p-tolyl)-3-(trifluoromethyl)-3H-pyrazole 
• 136603-54-8 3-carbomethoxy-5-trifluoromethyl-5-(p-tolyl)pyrazole 
• 136603-55-9 3,4-bis(carbomethoxy)-5-(p-tolyl)pyrazole 
• 136603-49-1 3-carbethoxy-5-trifluoromethyl-5-(p-tolyl)-2-pyrazoline 
• 1427218-54-9 3-(4-methylphenyl)-3-(trifluoromethyl)isoindolin-1-one 

Relevant articles and documents

Is Magnetic Bistability of Carbenes a General Phenomenon? Isolation of Simple Aryl(trifluoromethyl)carbenes in Both Their Singlet and Triplet States

p-Tolyl(trifluoromethyl)carbene and the related fluorenyl(trifluoromethyl)carbene were synthesized in solid argon and characterized by IR, UV-vis, and electron paramagnetic resonance spectroscopy as well as by quantum mechanical calculations. The carbenes

Diversity-oriented approach to CF3CHF-, CF3CFBr-, CF3CF2-, (CF3)2CH-, and CF3(SCF3)CH-substituted arenes from 1-(Diazo-2,2,2-trifluoroethyl)arenes

Arenes substituted with perfluoroalkyl groups are attractive targets for drug and agrochemical development. Exploiting the carbenic character of donor/acceptor diazo compounds, a diversity-oriented synthesis of perfluoroalkylated arenes, for late stage fluorofunctionalization, is described. The reaction of 1-(diazo-2,2,2-trifluoroethyl)arenes with HF, F/Br, F2, CF3H, and CF3SH sources give direct access to a variety of perfluoroalkyl-substituted arenes presenting with incremental fluorine content. The value of this approach is also demonstrated for radiochemistry and positron emission tomography with the [18F]-labeling of CF3CHF-, CF3CBrF-, and CF3CF2-arenes from [18F]fluoride.